Suppression of Ethanol-Reinforced Behavior by Naltrexone Is Associated with Attenuation of the Ethanol-Induced Increase in Dialysate Dopamine Levels in the Nucleus Accumbens

The opiate antagonist naltrexone suppresses ethanol-reinforced behavior in animals and decreases ethanol intake in humans. However, the mechanisms underlying these actions are not well understood. Experiments were designed to test the hypothesis that naltrexone attenuates the rewarding properties of...

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Veröffentlicht in:	The Journal of neuroscience 1998-12, Vol.18 (24), p.10663-10671
Hauptverfasser:	Gonzales, Rueben A, Weiss, Friedbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Dialysis Solutions - chemistry Dopamine - analysis Dose-Response Relationship, Drug Ethanol - administration & dosage Ethanol - antagonists & inhibitors Ethanol - blood Ethanol - pharmacology Male Microdialysis Naltrexone - pharmacology Narcotic Antagonists - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Rats Rats, Wistar Self Administration
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