Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons

Cell cultures were used to analyze the role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development of synaptic transmission. Neurons obtained from embryonic day 18 (E18) rat hippocampus and cultured for 2 weeks exhibited extensive spontaneous synaptic activity. By c...

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Veröffentlicht in:	The Journal of neuroscience 1998-09, Vol.18 (18), p.7256-7271
Hauptverfasser:	Vicario-Abejon, Carlos, Collin, Carlos, McKay, Ronald D. G, Segal, Menahem
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Animals Brain Chemistry - physiology Brain-Derived Neurotrophic Factor - metabolism Calcium-Binding Proteins - analysis Cell Differentiation - physiology Cell Size - physiology Cells, Cultured Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology gamma-Aminobutyric Acid - physiology Hippocampus - cytology Kinetics Membrane Glycoproteins - analysis Membrane Potentials - drug effects Membrane Potentials - physiology Microscopy, Electron Nerve Growth Factors - metabolism Nerve Tissue Proteins - analysis Neural Inhibition - physiology Neurons - chemistry Neurons - cytology Neurons - physiology Neurotrophin 3 Picrotoxin - pharmacology Rats Receptors, Glutamate - analysis Synapses - chemistry Synapses - physiology Synapses - ultrastructure Synapsins - analysis Synaptic Vesicles - chemistry Synaptotagmins
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