When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?
The involvement of metabotropic glutamate receptors (mGluRs) in hippocampal long-term potentiation (LTP) is a matter of controversial debate. Using [Ca2+]i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the effic...
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| Veröffentlicht in: | The Journal of neuroscience 1998-08, Vol.18 (16), p.6071-6080 |
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| creator | Wilsch, Volker W Behnisch, Thomas Jager, Tino Reymann, Klaus G Balschun, Detlef |
| description | The involvement of metabotropic glutamate receptors (mGluRs) in hippocampal long-term potentiation (LTP) is a matter of controversial debate. Using [Ca2+]i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the efficacy of the broad-spectrum mGluR-antagonist (S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and of (S)-4-carboxy-phenylglycine (4-CPG), a selective antagonist at class I mGluRs, in LTP is contingent on the tetanization strength and the resulting [Ca2+]i response. As indicated by experiments in which we blocked voltage-dependent calcium channels (VDCCs) and intracellular Ca2+ stores (ICSs), the functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca2+ from ICSs for induction. During strong tetanic stimulation, this Ca2+ source is functionally bypassed by activating VDCCs. |
| doi_str_mv | 10.1523/jneurosci.18-16-06071.1998 |
| format | Article |
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Using [Ca2+]i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the efficacy of the broad-spectrum mGluR-antagonist (S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and of (S)-4-carboxy-phenylglycine (4-CPG), a selective antagonist at class I mGluRs, in LTP is contingent on the tetanization strength and the resulting [Ca2+]i response. As indicated by experiments in which we blocked voltage-dependent calcium channels (VDCCs) and intracellular Ca2+ stores (ICSs), the functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca2+ from ICSs for induction. 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Using [Ca2+]i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the efficacy of the broad-spectrum mGluR-antagonist (S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and of (S)-4-carboxy-phenylglycine (4-CPG), a selective antagonist at class I mGluRs, in LTP is contingent on the tetanization strength and the resulting [Ca2+]i response. As indicated by experiments in which we blocked voltage-dependent calcium channels (VDCCs) and intracellular Ca2+ stores (ICSs), the functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca2+ from ICSs for induction. During strong tetanic stimulation, this Ca2+ source is functionally bypassed by activating VDCCs.</description><subject>Animals</subject><subject>Benzoates - pharmacology</subject><subject>Calcium - metabolism</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - pharmacology</subject><subject>Hippocampus - physiology</subject><subject>Hippocampus - ultrastructure</subject><subject>In Vitro Techniques</subject><subject>Intracellular Membranes - metabolism</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Long-Term Potentiation - physiology</subject><subject>Male</subject><subject>Microscopy, Confocal</subject><subject>Muscle Contraction - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Metabotropic Glutamate - antagonists & inhibitors</subject><subject>Receptors, Metabotropic Glutamate - physiology</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EKqHwCEgWC1hNsD0e28OCqopKCQotKq26tBznOnE1Mw62h4i3xyFRBStWtnR-dK4-hN5QMqUNq98_DDDGkKyfUlVRURFBJJ3StlVP0KQ42opxQp-iCWGSVIJL_hy9SOmBECIJlSfopBWtqgmboPv7DQz4PAKedSYlPMdfIZtlyDFsvcWX3ZhNbzLgG7CwzSEmfFV-KZn4C7sQ8SIM6-oWYo-_hQxD9ib7MJy9RM-c6RK8Or6n6O7Txe3sc7W4vpzPzheVbRqSKyetBVi2zHBRc6XKLMHalWt5LaiSVipnWK0aq1aUNq42xq6Ek864pgG3FPUp-njo3Y7LHla2LIim09vo-7JQB-P1v8rgN3odfmoh25oRVgreHgti-DFCyrr3yULXmQHCmLQipJFSqP8aqeCKi4YX44eD0RZGKYJ7XEOJ3vPTX64u7m6uv8_mmqqS03_46T2_En799z2P0SOwor876Bu_3ux8BJ1603XFTfVutzv07evq3xKAqFg</recordid><startdate>19980815</startdate><enddate>19980815</enddate><creator>Wilsch, Volker W</creator><creator>Behnisch, Thomas</creator><creator>Jager, Tino</creator><creator>Reymann, Klaus G</creator><creator>Balschun, Detlef</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980815</creationdate><title>When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?</title><author>Wilsch, Volker W ; Behnisch, Thomas ; Jager, Tino ; Reymann, Klaus G ; Balschun, Detlef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-f7cceeb92a463488698629df9436187c78fa2385c8d115f3aacd6f7faf55efb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Benzoates - pharmacology</topic><topic>Calcium - metabolism</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - pharmacology</topic><topic>Hippocampus - physiology</topic><topic>Hippocampus - ultrastructure</topic><topic>In Vitro Techniques</topic><topic>Intracellular Membranes - metabolism</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Long-Term Potentiation - physiology</topic><topic>Male</topic><topic>Microscopy, Confocal</topic><topic>Muscle Contraction - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Metabotropic Glutamate - antagonists & inhibitors</topic><topic>Receptors, Metabotropic Glutamate - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilsch, Volker W</creatorcontrib><creatorcontrib>Behnisch, Thomas</creatorcontrib><creatorcontrib>Jager, Tino</creatorcontrib><creatorcontrib>Reymann, Klaus G</creatorcontrib><creatorcontrib>Balschun, Detlef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilsch, Volker W</au><au>Behnisch, Thomas</au><au>Jager, Tino</au><au>Reymann, Klaus G</au><au>Balschun, Detlef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1998-08-15</date><risdate>1998</risdate><volume>18</volume><issue>16</issue><spage>6071</spage><epage>6080</epage><pages>6071-6080</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>The involvement of metabotropic glutamate receptors (mGluRs) in hippocampal long-term potentiation (LTP) is a matter of controversial debate. Using [Ca2+]i measurements by confocal laser scanning microscopy and field recordings of EPSPs (fEPSPs) in the hippocampal CA1-region, we found that the efficacy of the broad-spectrum mGluR-antagonist (S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and of (S)-4-carboxy-phenylglycine (4-CPG), a selective antagonist at class I mGluRs, in LTP is contingent on the tetanization strength and the resulting [Ca2+]i response. As indicated by experiments in which we blocked voltage-dependent calcium channels (VDCCs) and intracellular Ca2+ stores (ICSs), the functional significance of class I mGluRs in LTP is confined to certain types of potentiation, which are induced by weak tetanization protocols and require the release of Ca2+ from ICSs for induction. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Benzoates - pharmacology Calcium - metabolism Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - physiology Glycine - analogs & derivatives Glycine - pharmacology Hippocampus - physiology Hippocampus - ultrastructure In Vitro Techniques Intracellular Membranes - metabolism Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Microscopy, Confocal Muscle Contraction - physiology Rats Rats, Wistar Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology |
| title | When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation? |
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