The Glutamate Transporter EAAT4 in Rat Cerebellar Purkinje Cells: A Glutamate-Gated Chloride Channel Concentrated near the Synapse in Parts of the Dendritic Membrane Facing Astroglia

Antibodies to an excitatory amino acid transporter (EAAT4) label a glycoprotein of approximately 65 kDa strongly in the cerebellum and weakly in the forebrain. Cross-linking of cerebellar proteins with bis(sulfosuccinimidyl) suberate before solubilization causes dimer bands of EAAT4 and both dimer a...

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Veröffentlicht in:	The Journal of neuroscience 1998-05, Vol.18 (10), p.3606-3619
Hauptverfasser:	Dehnes, Yvette, Chaudhry, Farrukh A, Ullensvang, Kyrre, Lehre, Knut P, Storm-Mathisen, Jon, Danbolt, Niels C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Transport System X-AG Animals Antibody Specificity Astrocytes - chemistry Astrocytes - cytology Astrocytes - physiology ATP-Binding Cassette Transporters - metabolism Biological Transport - physiology Carrier Proteins - metabolism Cell Communication - physiology Chloride Channels - metabolism Dendrites - chemistry Dendrites - metabolism Dendrites - ultrastructure Excitatory Amino Acid Transporter 1 Excitatory Amino Acid Transporter 2 Excitatory Amino Acid Transporter 3 Excitatory Amino Acid Transporter 4 Glutamate Plasma Membrane Transport Proteins Glutamic Acid - metabolism Immunoblotting Immunohistochemistry Microscopy, Immunoelectron Molecular Sequence Data Neurotransmitter Agents - metabolism Purkinje Cells - cytology Purkinje Cells - metabolism Purkinje Cells - ultrastructure Rabbits Rats Rats, Wistar Receptors, Glutamate - analysis Receptors, Glutamate - immunology Receptors, Glutamate - metabolism Symporters Synapses - chemistry Synapses - metabolism Tissue Embedding
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