Brain-Derived Neurotrophic Factor and Basic Fibroblast Growth Factor Downregulate NMDA Receptor Function in Cerebellar Granule Cells

Evidence has accumulated to suggest that the NMDA glutamate receptor subtype plays an important role in neuronal degeneration evoked by hypoxia, ischemia, or trauma. Cerebellar granule cells in culture are vulnerable to NMDA-induced neuronal excitotoxicity. In these cells, brain-derived neurotrophic...

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Veröffentlicht in:	The Journal of neuroscience 1998-10, Vol.18 (19), p.7953-7961
Hauptverfasser:	Brandoli, Cinzia, Sanna, Angela, De Bernardi, Maria A, Follesa, Paolo, Brooker, Gary, Mocchetti, Italo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - pharmacology Calcium - metabolism Cerebellum - cytology Down-Regulation - drug effects Excitatory Amino Acid Agonists - pharmacology Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - pharmacology N-Methylaspartate - pharmacology Neurons - chemistry Neurons - metabolism Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism RNA, Messenger - analysis
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