Metabotropic Glutamate Receptors Negatively Regulate Melatonin Synthesis in Rat Pinealocytes

Rat pinealocytes receive noradrenergic innervation that stimulates melatonin synthesis in a cAMP-mediated manner. In addition to melatonin, we showed previously that pinealocytes secrete L-glutamate through an exocytic mechanism. The released glutamate inhibits norepinephrine (NE)-dependent melatoni...

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Veröffentlicht in:	The Journal of neuroscience 1998-03, Vol.18 (6), p.2056-2062
Hauptverfasser:	Yamada, Hiroshi, Yatsushiro, Shouki, Ishio, Shougo, Hayashi, Mitsuko, Nishi, Tsuyoshi, Yamamoto, Akitsugu, Futai, Masamitsu, Yamaguchi, Akihito, Moriyama, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Glutamic Acid - pharmacology GTP-Binding Proteins - metabolism Melatonin - antagonists & inhibitors Melatonin - biosynthesis Norepinephrine - pharmacology Pineal Gland - cytology Pineal Gland - metabolism Rats Rats, Wistar Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - physiology Tissue Distribution
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