Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS

In this report, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) is an anterograde neurotrophic factor in the CNS and have focused on central noradrenergic neurons that synthesize BDNF. Double-label immunocytochemistry for BDNF and dopamine-beta-hydroxylase (DBH), a marker...

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Veröffentlicht in:	The Journal of neuroscience 1998-04, Vol.18 (8), p.2808-2821
Hauptverfasser:	Fawcett, James P, Bamji, Shernaz X, Causing, Carrie G, Aloyz, Raquel, Ase, Ariel R, Reader, Tomas A, McLean, John H, Miller, Freda D
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Axotomy Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - secretion Cell Death - physiology Cell Division - physiology Cell Survival - physiology Cerebral Cortex - cytology Cerebral Cortex - growth & development Dopamine beta-Hydroxylase - metabolism Facial Nerve - cytology Female Gene Expression Regulation, Developmental - physiology Heterozygote Male Mice Mice, Transgenic Motor Neurons - cytology Nerve Regeneration - physiology Neurons, Afferent - cytology Neurons, Afferent - enzymology Neurons, Afferent - ultrastructure Norepinephrine - physiology Presynaptic Terminals - chemistry Presynaptic Terminals - enzymology
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