Dendritic cells and regulatory T cells expressing CCR4 provide resistance to coxsackievirus B5-induced pancreatitis

Type B coxsackieviruses (CVB) are enteroviruses responsible for a common infectious myocarditis and pancreatitis. DCs and regulatory T cells (Tregs) are key players in controlling virus replication and regulating the immune response and tissue damage, respectively. However, the mechanisms underlying...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.14766-11, Article 14766
Hauptverfasser:	Françozo, Marcela C. S., Costa, Frederico R. C., Guerra-Gomes, Isabel C., Silva, João S., Sesti-Costa, Renata
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/31 38 38/77 631/250/2499 631/250/2504/133/2505 631/250/98 64/60 692/699/255/2514 82 82/51 Adoptive transfer Animals CCL17 protein CD4 antigen CD8 antigen Cell activation Cell adhesion & migration Cell Movement Chemokine CCL17 - immunology Chronic infection Coxsackievirus Infections - complications Coxsackievirus Infections - immunology Coxsackievirus Infections - pathology Coxsackieviruses Dendritic cells Dendritic Cells - immunology Dendritic Cells - pathology Enterovirus B, Human - immunology Heart diseases Humanities and Social Sciences Immune response Immunoregulation Infections Interleukin 12 Leukocyte migration Lymph nodes Lymphocytes Lymphocytes T Mice, Inbred C57BL multidisciplinary Myocarditis Pancreas Pancreatitis Pancreatitis - etiology Pancreatitis - immunology Pancreatitis - pathology Pancreatitis - virology Receptors, CCR4 - immunology Science Science (multidisciplinary) T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology β-Interferon γ-Interferon
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