Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches

With the mechanistic understanding of immune checkpoints and success in checkpoint blockade using antibodies for the treatment of certain cancers, immunotherapy has become one of the hottest areas in cancer research, with promise of long‐lasting therapeutic effect. Currently, however, only a proport...

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Veröffentlicht in:	The Journal of pathology 2019-10, Vol.249 (2), p.151-165
Hauptverfasser:	Song, Dongkui, Powles, Thomas, Shi, Lei, Zhang, Lirong, Ingersoll, Molly A, Lu, Yong‐Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravesical Animals Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology Bacillus Calmette-Guerin vaccine bacillus Calmette–Guérin BCG BCG Vaccine - administration & dosage BCG Vaccine - adverse effects biomarkers Bladder cancer Cancer Cancer immunotherapy Health risk assessment Humans Immune checkpoint immune checkpoint blockade Immune response Immunology Immunotherapy Immunotherapy - methods intravesical instillation Life Sciences model system Molecular Targeted Therapy PD-L1 protein PD‐1/PD‐L1 inhibitors Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Review Signal Transduction Tumor Escape - drug effects Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - pathology
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