Mucosal gene expression changes induced by anti‐TNF treatment in inflammatory bowel disease patients

In the last two decades anti‐tumor necrosis factor (anti‐TNF) therapy for inflammatory bowel disease (IBD) has been widely used to induce and maintain clinical and endoscopical remission, completely changing management of the disease. In this study, we aimed to identify gene expression changes in in...

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Veröffentlicht in:	Drug development research 2019-09, Vol.80 (6), p.831-836
Hauptverfasser:	Milanesi, Elena, Dobre, Maria, Manuc, Teodora E., Becheanu, Gabriel, Tieranu, Cristian G., Ionescu, Elena M., Manuc, Mircea
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐ASA Adult anti‐TNF ATP Binding Cassette Transporter, Subfamily B - genetics Colitis, Ulcerative - genetics Colon Crohn disease Crohn Disease - genetics Crohn's disease Disease control Female Gene expression Gene Expression Regulation - drug effects Humans Inflammatory bowel disease Inflammatory bowel diseases Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Lipocalin-2 - genetics Male Medical treatment Mesalamine - pharmacology Middle Aged Mucosa Nitric Oxide Synthase Type II - genetics Patients Remission Trefoil Factor-1 - genetics Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-TNF Ulcerative colitis
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