Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

Microscopy of Lewy bodies in Parkinson’s disease (PD) suggests they are not solely filamentous deposits of α-synuclein (αS) but also contain vesicles and other membranous material. We previously reported the existence of native αS tetramers/multimers and described engineered mutations of the αS KTKE...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-10, Vol.116 (41), p.20760-20769
Hauptverfasser:	Imberdis, Thibaut, Negri, Joseph, Ramalingam, Nagendran, Terry-Kantor, Elizabeth, Ho, Gary P. H., Fanning, Saranna, Stirtz, Georgia, Kim, Tae-Eun, Levy, Oren A., Young-Pearse, Tracy L., Selkoe, Dennis, Dettmer, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Automation Biological Sciences Cell culture Cell Line Desaturase Dihydroxyphenylalanine Drug development Fatty acids Fluorescence High-Throughput Screening Assays Humans Inclusion Bodies - drug effects Inclusions Inhibitors Levodopa Lewy bodies Lipids Lipids - analysis Mice Mice, Transgenic Microscopy Models, Biological Modulators Monomers Movement disorders Mutants Mutation Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - pathology Neurodegenerative diseases Neuromodulation Neurons Neurotoxicity Parkinson's disease Phenotypes Phosphorylation PNAS Plus Small Molecule Libraries - pharmacology Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - antagonists & inhibitors Stearoyl-CoA Desaturase - metabolism Synuclein Tacrolimus Toxicity Transgenic mice Trifluoperazine
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