Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation

Inorganic arsenic is an environmental carcinogen that poses a major global public health risk. A high percentage of drinking water from wells in the U.S. contains higher-than-normal levels of arsenic, suggesting an increased risk of arsenic-induced deleterious effects. In addition to primary prevent...

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Veröffentlicht in:	Toxicology and applied pharmacology 2019-09, Vol.378, p.114606-114606, Article 114606
Hauptverfasser:	He, Jun, Liu, Weitao, Ge, Xin, Wang, Gao-Chan, Desai, Vilas, Wang, Shaomin, Mu, Wei, Bhardwaj, Vikas, Seifert, Erin, Liu, Ling-Zhi, Bhushan, Alok, Peiper, Stephen C., Jiang, Bing-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation, Metabolic - drug effects Arsenic Arsenic - adverse effects Carcinogenesis - drug effects Cell Line DNA methylation DNA Methylation - drug effects Glycolysis Glycolysis - drug effects Humans MicroRNAs - genetics miR-199a-5p PKM2 Sp1 Sp1 Transcription Factor - genetics
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