EZH2 promotes invasion and tumour glycolysis by regulating STAT3 and FoxO1 signalling in human OSCC cells

The enhancer of zeste homolog 2 (EZH2), known as a member of the polycomb group (PcG) proteins, is an oncogene overexpressed in a variety of human cancers. Here, we found that EZH2 correlated with poor survival of oral squamous cell carcinoma (OSCC) patients using immunohistochemistry staining. EZH2...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-10, Vol.23 (10), p.6942-6954
Hauptverfasser:	Zheng, Min, Cao, Ming‐xin, Luo, Xiao‐jie, Li, Li, Wang, Ke, Wang, Sha‐sha, Wang, Hao‐fan, Tang, Ya‐jie, Tang, Ya‐ling, Liang, Xin‐hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation Cell survival Down-Regulation - genetics enhancer of zeste homolog 2 Enhancer of Zeste Homolog 2 Protein - metabolism Epithelial-Mesenchymal Transition - genetics epithelial‐mesenchymal transition Experiments Female Forkhead Box Protein O1 - metabolism FoxO1 FOXO1 protein Gene Expression Regulation, Neoplastic Glycolysis Homology Humans Immunoglobulins Immunohistochemistry invasion Male Mesenchyme Metabolism Metastasis Mice, Inbred BALB C Mice, Nude Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology mRNA Multivariate Analysis Neoplasm Invasiveness Oral cancer Oral squamous cell carcinoma Original Phosphorylation Polycomb group proteins Prognosis Proportional Hazards Models Prostate cancer Proteins Signal Transduction Squamous cell carcinoma STAT3 Stat3 protein STAT3 Transcription Factor - metabolism Studies Survival Analysis Tumors tumour glycolysis Xenografts
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