The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding
The increasing prevalence of type 1 diabetes mellitus (DM) has made it necessary to have new markers for early detection of diabetic nephropathy. Renal resistive index (RI) by using renal Doppler can be a helpful tool in detecting functional alterations in renal hemodynamics. This study was conducte...
Gespeichert in:
Veröffentlicht in: | Annals of translational medicine 2019-09, Vol.7 (17), p.422-422 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 422 |
---|---|
container_issue | 17 |
container_start_page | 422 |
container_title | Annals of translational medicine |
container_volume | 7 |
creator | Maksoud, Abeer Ahmed Abdel Sharara, Sherine Mohamed Nanda, Amit Khouzam, Rami N. |
description | The increasing prevalence of type 1 diabetes mellitus (DM) has made it necessary to have new markers for early detection of diabetic nephropathy. Renal resistive index (RI) by using renal Doppler can be a helpful tool in detecting functional alterations in renal hemodynamics. This study was conducted on 100 children and adolescents with type 1 DM. They were further subdivided into two equal subgroups: group 1 with type 1 DM and normo-albuminuria [urinary albumin excretion (UAE) 30 mg/24 hours). There were 37 males (37%) and 63 females (63%); their mean ages were 13.6±2.53 (range, 10–19) years and mean disease duration was 8.867±2.260 (range, 5–13) years. Progressive increase in RI was significantly associated with increased disease duration more than 10 years, elevated serum HbA1c more than 7.5% and early pubertal stages. While not significantly related to sex, weight, height, blood pressure or serum lipid profile, diabetic micro-vascular complications (nephropathy and sensory neuropathy) were more prevalent among patients with RI more than 0.58. Renal RI could be a useful complementary test for the evaluation of functional alterations in renal hemodynamics in the early stages of diabetic nephropathy. |
doi_str_mv | 10.21037/atm.2019.08.65 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6787385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2310291158</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-6170574ec524d77de4e797388b9958698d51238b82790fd9588a8df441b4119e3</originalsourceid><addsrcrecordid>eNpVkUuPFCEUhYnROJN21m5ZuukeHkUBLkzMxFGTSdyMa0LBrW6UghaoVn-Lf1bGnhjd3Et4fOceDkIvKdkxSri8tm3ZMUL1jqjdKJ6gS8aJ2ArF9dN_1hfoqtYvhBDKqOaEPEcXnI4j4Yxeol_3B8AFko291lBbOAEOycMPbCu2OMF37PJyjLBAarb8xC3n2As-FvDBNbwEV_LJVrdGW7APdoIW3PlRcLaFnGonYncI0XclbJPH1ucI1XVkfd1V9iWvyU8F7NeQ9njuA_T-Aj2bbaxw9dg36PPtu_ubD9u7T-8_3ry927rupm1HKomQAzjBBi-lhwGkllypSWuhRq28oIyrSTGpyez7nrLKz8NAp4FSDXyD3py5x3VawD9MVWw0xxKWbthkG8z_JykczD6fzChV1xEd8OoRUPK3FWozS-jmYrQJ8loN45QwTWlPY4Ouz1f7p9VaYP4rQ4n5k6rpqZqHVA1RZhT8N06xl90</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2310291158</pqid></control><display><type>article</type><title>The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Maksoud, Abeer Ahmed Abdel ; Sharara, Sherine Mohamed ; Nanda, Amit ; Khouzam, Rami N.</creator><creatorcontrib>Maksoud, Abeer Ahmed Abdel ; Sharara, Sherine Mohamed ; Nanda, Amit ; Khouzam, Rami N.</creatorcontrib><description>The increasing prevalence of type 1 diabetes mellitus (DM) has made it necessary to have new markers for early detection of diabetic nephropathy. Renal resistive index (RI) by using renal Doppler can be a helpful tool in detecting functional alterations in renal hemodynamics. This study was conducted on 100 children and adolescents with type 1 DM. They were further subdivided into two equal subgroups: group 1 with type 1 DM and normo-albuminuria [urinary albumin excretion (UAE) <30 mg/24 hours], and group 2 with type 1 DM and hyper-albuminuria (increased UAE >30 mg/24 hours). There were 37 males (37%) and 63 females (63%); their mean ages were 13.6±2.53 (range, 10–19) years and mean disease duration was 8.867±2.260 (range, 5–13) years. Progressive increase in RI was significantly associated with increased disease duration more than 10 years, elevated serum HbA1c more than 7.5% and early pubertal stages. While not significantly related to sex, weight, height, blood pressure or serum lipid profile, diabetic micro-vascular complications (nephropathy and sensory neuropathy) were more prevalent among patients with RI more than 0.58. Renal RI could be a useful complementary test for the evaluation of functional alterations in renal hemodynamics in the early stages of diabetic nephropathy.</description><identifier>ISSN: 2305-5839</identifier><identifier>EISSN: 2305-5839</identifier><identifier>DOI: 10.21037/atm.2019.08.65</identifier><identifier>PMID: 31660321</identifier><language>eng</language><publisher>AME Publishing Company</publisher><subject>Review</subject><ispartof>Annals of translational medicine, 2019-09, Vol.7 (17), p.422-422</ispartof><rights>2019 Annals of Translational Medicine. All rights reserved. 2019 Annals of Translational Medicine.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c300t-6170574ec524d77de4e797388b9958698d51238b82790fd9588a8df441b4119e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787385/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787385/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Maksoud, Abeer Ahmed Abdel</creatorcontrib><creatorcontrib>Sharara, Sherine Mohamed</creatorcontrib><creatorcontrib>Nanda, Amit</creatorcontrib><creatorcontrib>Khouzam, Rami N.</creatorcontrib><title>The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding</title><title>Annals of translational medicine</title><description>The increasing prevalence of type 1 diabetes mellitus (DM) has made it necessary to have new markers for early detection of diabetic nephropathy. Renal resistive index (RI) by using renal Doppler can be a helpful tool in detecting functional alterations in renal hemodynamics. This study was conducted on 100 children and adolescents with type 1 DM. They were further subdivided into two equal subgroups: group 1 with type 1 DM and normo-albuminuria [urinary albumin excretion (UAE) <30 mg/24 hours], and group 2 with type 1 DM and hyper-albuminuria (increased UAE >30 mg/24 hours). There were 37 males (37%) and 63 females (63%); their mean ages were 13.6±2.53 (range, 10–19) years and mean disease duration was 8.867±2.260 (range, 5–13) years. Progressive increase in RI was significantly associated with increased disease duration more than 10 years, elevated serum HbA1c more than 7.5% and early pubertal stages. While not significantly related to sex, weight, height, blood pressure or serum lipid profile, diabetic micro-vascular complications (nephropathy and sensory neuropathy) were more prevalent among patients with RI more than 0.58. Renal RI could be a useful complementary test for the evaluation of functional alterations in renal hemodynamics in the early stages of diabetic nephropathy.</description><subject>Review</subject><issn>2305-5839</issn><issn>2305-5839</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkUuPFCEUhYnROJN21m5ZuukeHkUBLkzMxFGTSdyMa0LBrW6UghaoVn-Lf1bGnhjd3Et4fOceDkIvKdkxSri8tm3ZMUL1jqjdKJ6gS8aJ2ArF9dN_1hfoqtYvhBDKqOaEPEcXnI4j4Yxeol_3B8AFko291lBbOAEOycMPbCu2OMF37PJyjLBAarb8xC3n2As-FvDBNbwEV_LJVrdGW7APdoIW3PlRcLaFnGonYncI0XclbJPH1ucI1XVkfd1V9iWvyU8F7NeQ9njuA_T-Aj2bbaxw9dg36PPtu_ubD9u7T-8_3ry927rupm1HKomQAzjBBi-lhwGkllypSWuhRq28oIyrSTGpyez7nrLKz8NAp4FSDXyD3py5x3VawD9MVWw0xxKWbthkG8z_JykczD6fzChV1xEd8OoRUPK3FWozS-jmYrQJ8loN45QwTWlPY4Ouz1f7p9VaYP4rQ4n5k6rpqZqHVA1RZhT8N06xl90</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Maksoud, Abeer Ahmed Abdel</creator><creator>Sharara, Sherine Mohamed</creator><creator>Nanda, Amit</creator><creator>Khouzam, Rami N.</creator><general>AME Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201909</creationdate><title>The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding</title><author>Maksoud, Abeer Ahmed Abdel ; Sharara, Sherine Mohamed ; Nanda, Amit ; Khouzam, Rami N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-6170574ec524d77de4e797388b9958698d51238b82790fd9588a8df441b4119e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Review</topic><toplevel>online_resources</toplevel><creatorcontrib>Maksoud, Abeer Ahmed Abdel</creatorcontrib><creatorcontrib>Sharara, Sherine Mohamed</creatorcontrib><creatorcontrib>Nanda, Amit</creatorcontrib><creatorcontrib>Khouzam, Rami N.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of translational medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maksoud, Abeer Ahmed Abdel</au><au>Sharara, Sherine Mohamed</au><au>Nanda, Amit</au><au>Khouzam, Rami N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding</atitle><jtitle>Annals of translational medicine</jtitle><date>2019-09</date><risdate>2019</risdate><volume>7</volume><issue>17</issue><spage>422</spage><epage>422</epage><pages>422-422</pages><issn>2305-5839</issn><eissn>2305-5839</eissn><abstract>The increasing prevalence of type 1 diabetes mellitus (DM) has made it necessary to have new markers for early detection of diabetic nephropathy. Renal resistive index (RI) by using renal Doppler can be a helpful tool in detecting functional alterations in renal hemodynamics. This study was conducted on 100 children and adolescents with type 1 DM. They were further subdivided into two equal subgroups: group 1 with type 1 DM and normo-albuminuria [urinary albumin excretion (UAE) <30 mg/24 hours], and group 2 with type 1 DM and hyper-albuminuria (increased UAE >30 mg/24 hours). There were 37 males (37%) and 63 females (63%); their mean ages were 13.6±2.53 (range, 10–19) years and mean disease duration was 8.867±2.260 (range, 5–13) years. Progressive increase in RI was significantly associated with increased disease duration more than 10 years, elevated serum HbA1c more than 7.5% and early pubertal stages. While not significantly related to sex, weight, height, blood pressure or serum lipid profile, diabetic micro-vascular complications (nephropathy and sensory neuropathy) were more prevalent among patients with RI more than 0.58. Renal RI could be a useful complementary test for the evaluation of functional alterations in renal hemodynamics in the early stages of diabetic nephropathy.</abstract><pub>AME Publishing Company</pub><pmid>31660321</pmid><doi>10.21037/atm.2019.08.65</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2305-5839 |
ispartof | Annals of translational medicine, 2019-09, Vol.7 (17), p.422-422 |
issn | 2305-5839 2305-5839 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6787385 |
source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
subjects | Review |
title | The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T23%3A29%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20renal%20resistive%20index%20as%20a%20new%20complementary%20tool%20to%20predict%20microvascular%20diabetic%20complications%20in%20children%20and%20adolescents:%20a%20groundbreaking%20finding&rft.jtitle=Annals%20of%20translational%20medicine&rft.au=Maksoud,%20Abeer%20Ahmed%20Abdel&rft.date=2019-09&rft.volume=7&rft.issue=17&rft.spage=422&rft.epage=422&rft.pages=422-422&rft.issn=2305-5839&rft.eissn=2305-5839&rft_id=info:doi/10.21037/atm.2019.08.65&rft_dat=%3Cproquest_pubme%3E2310291158%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2310291158&rft_id=info:pmid/31660321&rfr_iscdi=true |