Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma

Trace elements are a possible risk factor for pancreatic ductal adenocarcinoma (PDAC). However, their role in the occurrence and persistence of KRAS mutations remains unstudied. There appear to be no studies analyzing biomarkers of trace elements and KRAS mutations in any human cancer. We aimed to d...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2019-10, Vol.60 (8), p.693-703
Hauptverfasser:	Gómez‐Tomás, Álvaro, Pumarega, José, Alguacil, Juan, Amaral, André F. S., Malats, Núria, Pallarès, Natàlia, Gasull, Magda, Porta, Miquel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Arsenic Biomarkers Biomarkers, Tumor - genetics Cadmium Cancer Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology etiology Humans Inductively coupled plasma mass spectrometry Iron K-Ras protein KRAS oncogene Manganese Mass spectrometry Mass spectroscopy Mutation Nails - chemistry Nickel Pancreas Pancreas - pathology Pancreatic cancer pancreatic ductal adenocarcinoma pancreatic neoplasm Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Polymerase chain reaction Prospective Studies Proto-Oncogene Proteins p21(ras) - genetics Risk analysis Risk factors Selenium Spain Statistical analysis Statistical methods Toenail Trace elements Trace Elements - analysis Tumors Vanadium
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