NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP

Olfactory bulb, as one of sensory organs opening to the outside, is susceptible to toxic environment and easy to deteriorate. Recent studies in Parkinson’s disease (PD) patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys have shown that abnormal α-synuclein is accumulate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2019-08, Vol.40 (8), p.991-998
Hauptverfasser:	Chen, Ying, Zhang, Qiu-shuang, Shao, Qian-hang, Wang, Shuo, Yuan, Yu-he, Chen, Nai-hong, Wang, Hong-bo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine alpha-Synuclein - metabolism Animals Basal ganglia Biomedical and Life Sciences Biomedicine Caspase Caspase-1 Central nervous system diseases Glial fibrillary acidic protein Hydroxylase IL-1β Immunology Inflammasomes Inflammasomes - metabolism Inflammation Internal Medicine Lesions Male Medical Microbiology Mice Mice, Inbred C57BL Monkeys Movement disorders MPTP Neurodegenerative diseases NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Olfaction Olfactory bulb Olfactory Bulb - drug effects Olfactory Bulb - pathology Olfactory glomeruli Organs Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - etiology Parkinson's disease Pathogenesis Pharmacology/Toxicology Phosphorylation Probenecid - pharmacology Protein Multimerization - drug effects Proteins Sense organs Signal Transduction - drug effects Smell Substantia nigra Synuclein TLR4 protein Toll-like receptors Tyrosine 3-monooxygenase Vaccine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!