Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

Palmitate (PA) exposure induces stress conditions featuring ROS accumulation and upregulation of p62 expression, resulting in autophagic flux blockage and cell apoptosis. Sulfuretin (Sul) is a natural product isolated from Rhus verniciflua Stokes; the cytoprotective effect of Sul on human hepatic L0...

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Veröffentlicht in:	Acta pharmacologica Sinica 2019-07, Vol.40 (7), p.908-918
Hauptverfasser:	Lu, Yu-ting, Xiao, Yu-feng, Li, Yu-feng, Li, Jia, Nan, Fa-jun, Li, Jing-ya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Animals Antioxidants - chemistry Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Autophagy-Related Protein 5 - metabolism Benzofurans - chemistry Benzofurans - pharmacology Biological activity Biomedical and Life Sciences Biomedicine Cell Line, Tumor Chloroquine Chloroquine - pharmacology Cytotoxicity Flavonoids - chemistry Flavonoids - pharmacology Flow cytometry Fluctuations Fluorescence Hepatocytes Hepatocytes - drug effects Humans Hydroxyl groups Immunology Internal Medicine Liver Medical Microbiology Mice Mitochondria Mitophagy - drug effects Molecular Structure Natural products Palmitic acid Phagocytosis Pharmacology/Toxicology Phenolic compounds Phenols Reactive Oxygen Species - metabolism Structure-Activity Relationship Vaccine Western blotting
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