Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells

Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone modifiers are often dysregulated in cancer development, thus they can serve as an excellent drug targets for cancer therapy. Here,...

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Veröffentlicht in:	Acta pharmacologica Sinica 2019-08, Vol.40 (8), p.1076-1084
Hauptverfasser:	Cao, Yue-peng, Sun, Jing-ya, Li, Mei-qian, Dong, Yu, Zhang, Yuan-heng, Yan, Jun, Huang, Rui-min, Yan, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis - physiology BIM protein Biomedical and Life Sciences Biomedicine Bladder cancer Body weight Cancer Cancer therapies Caspase Caspase-3 Cell Proliferation - physiology Cell Survival - drug effects Cell viability Chemotherapy Cisplatin Cytotoxicity Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Epigenetics Gemcitabine Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques Histocompatibility Antigens - genetics Histone H3 Histone-Lysine N-Methyltransferase - antagonists & inhibitors Histone-Lysine N-Methyltransferase - genetics Histones Humans Immunohistochemistry Immunology Internal Medicine Male Medical Microbiology Metastases Mice, Nude Pharmacology/Toxicology Quinazolines - pharmacology Quinazolines - therapeutic use siRNA Therapeutic applications Urinary bladder Urinary Bladder - pathology Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Vaccine Viability Xenografts
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