Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis to Support EGFR Signaling

Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSCs) contribute to this poor prognosis by driving therapeutic resistance and maintenance of cellular heterogeneity. To understand the molecular processes essential for GSC maintenan...

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Veröffentlicht in:	Cancer discovery 2019-06, Vol.9 (9), p.1248-1267
Hauptverfasser:	Gimple, Ryan C., Kidwell, Reilly L., Kim, Leo J.Y., Sun, Tengqian, Gromovsky, Anthony D., Wu, Qiulian, Wolf, Megan, Lv, Deguan, Bhargava, Shruti, Jiang, Li, Prager, Briana C., Wang, Xiuxing, Ye, Qing, Zhu, Zhe, Zhang, Guoxin, Dong, Zhen, Zhao, Linjie, Lee, Derrick, Bi, Junfeng, Sloan, Andrew E., Mischel, Paul S., Brown, J. Mark, Cang, Hu, Huan, Tao, Mack, Stephen C., Xie, Qi, Rich, Jeremy N.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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