Estradiol-Treated Mesenchymal Stem Cells Improve Myocardial Recovery After Ischemia

Background Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Our lab has recently shown that gender differences exist in mesenchymal stem cell (MSC) paracrine function. Estrogen is implicated in...

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Veröffentlicht in:	The Journal of surgical research 2009-04, Vol.152 (2), p.319-324
Hauptverfasser:	Erwin, Graham S, Crisostomo, Paul R., M.D, Wang, Yue, Ph.D, Wang, Meijing, M.D., M.S, Markel, Troy A., M.D, Guzman, Mike, B.S, Sando, Ian C., B.S, Sharma, Rahul, B.S, Meldrum, Daniel R., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system cardioprotection Cell Culture Techniques - methods Coronary heart disease Diastole - drug effects Diastole - physiology Estradiol - pharmacology estrogen General aspects Heart Heart - drug effects Heart - physiology Heart - physiopathology Male Medical sciences Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Myocardial Ischemia - physiopathology Myocardial Ischemia - surgery Myocardial Reperfusion - methods paracrine Rats Rats, Sprague-Dawley sex hormones Surgery Vascular Endothelial Growth Factor A - metabolism VEGF Ventricular Function, Left - drug effects Ventricular Function, Left - physiology
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