Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding

Preclinical data have shown that the excitatory metabotropic Gα -coupled glutamate receptor, mGluR5, has a role in substance abuse and relapse. However, little is known about the contribution of mGluR5 to the expression of conditioned responding elicited by appetitive Pavlovian cues. We investigated...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-08, Vol.44 (9), p.1524-1533
Hauptverfasser:	Khoo, Shaun Yon-Seng, LeCocq, Mandy Rita, Deyab, Ghislaine E, Chaudhri, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Allosteric Regulation Amygdala Animal behavior Animals Appetitive Behavior - drug effects Appetitive Behavior - physiology Auditory discrimination Basolateral Nuclear Complex - drug effects Basolateral Nuclear Complex - metabolism Brain Conditioned stimulus Conditioning Conditioning, Classical - drug effects Conditioning, Classical - physiology Dizocilpine Maleate - pharmacology Drug abuse Excitatory Amino Acid Antagonists - pharmacology Fructose Glucose Glutamic acid receptors (metabotropic) Male Nucleus accumbens Pyridines - pharmacology Rats, Long-Evans Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors Receptor, Metabotropic Glutamate 5 - metabolism Rodents Sugar Thiazoles - pharmacology
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