Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial

Short- and long-term antidepressant effects of deep brain stimulation (DBS) in treatment-resistant depression (TRD) have been demonstrated for several brain targets in open-label studies. For two stimulation targets, pivotal randomized trials have been conducted; both failed a futility analysis. We...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-06, Vol.44 (7), p.1224-1232
Hauptverfasser:	Coenen, Volker A, Bewernick, Bettina H, Kayser, Sarah, Kilian, Hannah, Boström, Jan, Greschus, Susanne, Hurlemann, René, Klein, Margaretha Eva, Spanier, Susanne, Sajonz, Bastian, Urbach, Horst, Schlaepfer, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antidepressants Brain Chronic illnesses Clinical trials Deep Brain Stimulation Depressive Disorder, Major - physiopathology Depressive Disorder, Major - therapy Depressive Disorder, Treatment-Resistant - physiopathology Depressive Disorder, Treatment-Resistant - therapy Female Forebrain Humans Implantation Male Medial forebrain bundle Medial Forebrain Bundle - physiopathology Mental depression Middle Aged Patients Randomization Stimulation Strabismus Treatment Outcome
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