White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents

Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to which ADHD symptomatology is associated with white matter microstructure and cerebral cortical...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-08, Vol.44 (9), p.1597-1603
Hauptverfasser:	Albaugh, Matthew D, Hudziak, James J, Ing, Alex, Chaarani, Bader, Barker, Edward, Jia, Tianye, Lemaitre, Herve, Watts, Richard, Orr, Catherine, Spechler, Philip A, Lepage, Claude, Fonov, Vladimir, Collins, Louis, Rioux, Pierre, Evans, Alan C, Banaschewski, Tobias, Bokde, Arun L W, Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H, Smolka, Michael N, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Garavan, Hugh, Potter, Alexandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Anisotropy Attention Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - physiopathology Attention Deficit Disorder with Hyperactivity - psychology Attention deficit hyperactivity disorder Brain - diagnostic imaging Brain - pathology Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Child Cortex Female Genome-wide association studies Genomes Humans Hyperactivity Male Microstructure Multifactorial Inheritance Neural Pathways - diagnostic imaging Neuroimaging Neurology Organ Size Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - pathology Risk Assessment Substantia alba White Matter - diagnostic imaging White Matter - pathology White People - genetics
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Zusammenfassung:	Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to which ADHD symptomatology is associated with white matter microstructure and cerebral cortical thickness in a large population-based sample of adolescents. Critically, we then test the extent to which multimodal correlates of ADHD symptomatology are related to ADHD polygenic risk score (PRS). Neuroimaging, genetic, and behavioral data were obtained from the IMAGEN study. A dimensional ADHD composite score was derived from multi-informant ratings of ADHD symptomatology. Using tract-based spatial statistics, whole brain voxel-wise regressions between fractional anisotropy (FA) and ADHD composite score were calculated. Local cortical thickness was regressed on ADHD composite score. ADHD PRS was based on a very recent genome-wide association study, and calculated using PRSice. ADHD composite score was negatively associated with FA in several white matter pathways, including bilateral superior and inferior longitudinal fasciculi (p
ISSN:	0893-133X 1740-634X
DOI:	10.1038/s41386-019-0383-y