Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis

Preclinical and human studies suggest that hippocampal dysfunction is a key factor in the onset of psychosis. People at Clinical High Risk for psychosis (CHR-P) present with a clinical syndrome that can include social withdrawal and have a 20-35% risk of developing psychosis in the next 2 years. Rec...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-06, Vol.44 (7), p.1300-1309
Hauptverfasser:	Davies, Cathy, Paloyelis, Yannis, Rutigliano, Grazia, Cappucciati, Marco, De Micheli, Andrea, Ramella-Cravaro, Valentina, Provenzani, Umberto, Antoniades, Mathilde, Modinos, Gemma, Oliver, Dominic, Stahl, Daniel, Murguia, Silvia, Zelaya, Fernando, Allen, Paul, Shergill, Sukhi, Morrison, Paul, Williams, Steve, Taylor, David, McGuire, Philip, Fusar-Poli, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adolescent Adult Blood flow Clinical trials Cross-Over Studies Crossovers Double-Blind Method Female Hippocampus Hippocampus - blood supply Hippocampus - drug effects Hippocampus - physiopathology Humans Intranasal administration Male Males Mental disorders Oxytocin Oxytocin - administration & dosage Perfusion Psychosis Psychotic Disorders - blood Psychotic Disorders - physiopathology Remission Risk Factors Social research Spin labeling Withdrawal Young Adult
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