Multiple Actions of Neurturin Correlate with Spatiotemporal Patterns of Ret Expression in Developing Chick Cranial Ganglion Neurons

The neurotrophic effects of neurturin (NRTN) on chick cranial ganglia were evaluated at various embryonic stages in vitro and related to its receptor expression. NRTN promoted the outgrowth and survival of ciliary ganglion neurons at early embryonic (E) stages (E6-E12), trigeminal ganglion neurons a...

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Veröffentlicht in:	The Journal of neuroscience 1999-10, Vol.19 (19), p.8476-8486
Hauptverfasser:	Hashino, Eri, Johnson, Eugene M., Jr, Milbrandt, Jeffrey, Shero, Marlene, Salvi, Richard J, Cohan, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - pharmacology Chick Embryo Ciliary Body - embryology Cochlea - embryology cranial ganglion Drosophila Proteins Ganglia, Parasympathetic - embryology Ganglia, Sensory - embryology Gene Expression Regulation, Developmental Morphogenesis Nerve Growth Factors - pharmacology Nerve Growth Factors - physiology Neurites - drug effects Neurites - physiology Neurons - cytology Neurons - drug effects Neurons - physiology Neurturin Organ Culture Techniques Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - genetics Ret protein Space life sciences Tretinoin - pharmacology Trigeminal Ganglion - embryology Vestibule, Labyrinth - embryology
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