Embryonic Neurons Adapt to the Inhibitory Proteoglycan Aggrecan by Increasing Integrin Expression

The primary mediators of cell migration during development, wound healing and metastasis, are receptors of the integrin family. In the developing and regenerating nervous system, chondroitin sulfate proteoglycans (CSPGs) inhibit the integrin-dependent migration of neuronal growth cones. Here we repo...

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Veröffentlicht in:	The Journal of neuroscience 1999-11, Vol.19 (22), p.10036-10043
Hauptverfasser:	Condic, Maureen L, Snow, Diane M, Letourneau, Paul C
Format:	Artikel
Sprache:	eng
Schlagworte:	aggrecan Aggrecans Animals Cells, Cultured Chick Embryo Chondroitin Sulfate Proteoglycans - pharmacology Extracellular Matrix Proteins Ganglia, Spinal - cytology Ganglia, Spinal - embryology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Integrin alpha3beta1 Integrin alpha6beta1 Integrins - genetics Lectins, C-Type Neurites - physiology Neurons - cytology Neurons - drug effects Neurons - physiology Protein Biosynthesis Proteoglycans - pharmacology Transcription, Genetic
Online-Zugang:	Volltext
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