Pain-Induced Analgesia Mediated by Mesolimbic Reward Circuits

We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in the anesthetized rat; f...

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Veröffentlicht in:	The Journal of neuroscience 1999-08, Vol.19 (16), p.7175-7181
Hauptverfasser:	Gear, Robert W, Aley, K. O, Levine, Jon D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia - methods Animals Electric Stimulation Limbic System - physiology Male Medulla Oblongata - physiology mesolimbic system Neural Pathways - physiology Pain - physiopathology Rats Rats, Sprague-Dawley Reward
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