Transmembrane Domain I Contributes to the Permeation Pathway for Serotonin and Ions in the Serotonin Transporter

Mutation of a conserved Asp (D98) in the rat serotonin (5HT) transporter (rSERT) to Glu (D98E) led to decreased 5HT transport capacity, diminished coupling to extracellular Na+ and Cl-, and a selective loss of antagonist potencies (cocaine, imipramine, and citalopram but not paroxetine or mazindol)...

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Veröffentlicht in:	The Journal of neuroscience 1999-06, Vol.19 (12), p.4705-4717
Hauptverfasser:	Barker, Eric L, Moore, Kimberly R, Rakhshan, Fariborz, Blakely, Randy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - pharmacology Alkaloids - pharmacology Amino Acid Substitution - physiology Animals Aspartic Acid Biological Transport - drug effects Biological Transport - genetics Calcium-Binding Proteins - analysis Calnexin Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cocaine - analogs & derivatives Cocaine - pharmacology COS Cells HeLa Cells Humans Imipramine - pharmacology Intracellular Membranes - chemistry Iodine Radioisotopes Ion Channel Gating - genetics Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Transport Proteins Molecular Sequence Data N,N-Dimethyltryptamine - pharmacology Nerve Tissue Proteins Oocytes - physiology Protein Structure, Tertiary Rats Sequence Homology, Amino Acid Serotonin - pharmacokinetics Serotonin Plasma Membrane Transport Proteins Serotonin Receptor Agonists - pharmacology Sodium Chloride - pharmacology Transfection Tritium Xenopus
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