Modulation of Learning and Anxiety by Corticotropin-Releasing Factor (CRF) and Stress: Differential Roles of CRF Receptors 1 and 2

The differential modulation of learning and anxiety by corticotropin-releasing factor (CRF) through CRF receptor subtypes 1 (CRFR1) and 2 (CRFR2) is demonstrated. As learning paradigm, context- and tone-dependent fear conditioning of the mouse was used. Injection of CRF into the dorsal hippocampus b...

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Veröffentlicht in:	The Journal of neuroscience 1999-06, Vol.19 (12), p.5016-5025
Hauptverfasser:	Radulovic, Jelena, Ruhmann, Andreas, Liepold, Thomas, Spiess, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Anxiety - physiopathology Behavior, Animal - drug effects Behavior, Animal - physiology Brain Chemistry - physiology Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Fear - physiology Hippocampus - chemistry Hippocampus - physiology Male Maze Learning - drug effects Maze Learning - physiology Mice Mice, Inbred BALB C Neuroprotective Agents - pharmacology Peptide Fragments - pharmacology Receptors, Corticotropin-Releasing Hormone - agonists Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - physiology Septal Nuclei - chemistry Septal Nuclei - physiology Stress, Psychological - physiopathology
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