Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

Nerve growth factor (NGF) is released through the constitutive secretory pathway from cells in peripheral tissues and nerves where it can act as a target-derived survival factor. In contrast, brain-derived neurotrophic factor (BDNF) appears to be processed in the regulated secretory pathway of brain...

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Veröffentlicht in:	The Journal of neuroscience 1999-03, Vol.19 (6), p.2069-2080
Hauptverfasser:	Mowla, S. Javad, Pareek, Sangeeta, Farhadi, Hooman F, Petrecca, Kevin, Fawcett, James P, Seidah, Nabil G, Morris, Stephen J, Sossin, Wayne S, Murphy, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - metabolism Electrophysiology Furin Hippocampus - cytology Hippocampus - metabolism Hippocampus - physiology Immunohistochemistry Mice - embryology Nerve Growth Factors - metabolism Neurons - metabolism Neurons - physiology Protein Precursors - metabolism Protein Processing, Post-Translational - drug effects Subtilisins - pharmacology Tissue Distribution
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