Long-Term Potentiation in the Hippocampal CA1 Region of Mice Lacking cGMP-Dependent Kinases Is Normal and Susceptible to Inhibition of Nitric Oxide Synthase

Long-term potentiation (LTP) is a potential cellular mechanism for learning and memory. The retrograde messenger nitric oxide (NO) is thought to induce LTP in the CA1 region of the hippocampus via activation of soluble guanylyl cyclase (sGC) and, ultimately, cGMP-dependent protein kinase (cGK). Two...

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Veröffentlicht in:	The Journal of neuroscience 1999-01, Vol.19 (1), p.48-55
Hauptverfasser:	Kleppisch, Thomas, Pfeifer, Alexander, Klatt, Peter, Ruth, Peter, Montkowski, Alexandra, Fassler, Reinhard, Hofmann, Franz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic GMP-Dependent Protein Kinases - deficiency Enzyme Inhibitors - pharmacology Excitatory Postsynaptic Potentials - drug effects Hippocampus - drug effects Hippocampus - metabolism Long-Term Potentiation Mice Mice, Inbred C57BL Niacinamide - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Oxadiazoles - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Reference Values Synaptic Transmission - drug effects
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