Immortalized Human Dorsal Root Ganglion Cells Differentiate into Neurons with Nociceptive Properties

A renewable source of human sensory neurons would greatly facilitate basic research and drug development. We had established previously conditionally immortalized human CNS cell lines that can differentiate into functional neurons (). We report here the development of an immortalized human dorsal ro...

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Veröffentlicht in:	The Journal of neuroscience 1999-07, Vol.19 (13), p.5420-5428
Hauptverfasser:	Raymon, Heather K, Thode, Silke, Zhou, Jiuying, Friedman, Glenn C, Pardinas, Jose R, Barrere, Christian, Johnson, Randolph M, Sah, Dinah W. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Capsaicin - pharmacology Cations - metabolism Cell Differentiation Cell Line Cell Lineage Cell Size Clone Cells - cytology Clone Cells - drug effects Clone Cells - metabolism Ganglia, Spinal - cytology Ganglia, Spinal - embryology Genes, myc - genetics Humans Ion Channel Gating Ligands Neurons, Afferent - cytology Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neurons, Afferent - physiology Nociceptors - physiology Pain Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Tetracycline - pharmacology Transcription Factors - analysis
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