Effectiveness of Partial and Full Influenza Vaccination Among Children Aged < 9 Years in Hong Kong, 2011–2019
Abstract Background Two doses of influenza vaccination are recommended for previously unvaccinated children aged
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| Veröffentlicht in: | The Journal of infectious diseases 2019-10, Vol.220 (10), p.1568-1576 |
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| container_title | The Journal of infectious diseases |
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| creator | Chua, Huiying Chiu, Susan S. Chan, Eunice L. Y. Feng, Shuo Kwan, Mike Y. W. Wong, Joshua S. C. Peiris, J. S. Malik Cowling, Benjamin J. |
| description | Abstract
Background
Two doses of influenza vaccination are recommended for previously unvaccinated children aged |
| doi_str_mv | 10.1093/infdis/jiz361 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6782104</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>26839588</jstor_id><oup_id>10.1093/infdis/jiz361</oup_id><sourcerecordid>26839588</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-3e79c35499f609e1dd031336f296f2710421c61317b2b8de61779830fe382c773</originalsourceid><addsrcrecordid>eNqFkU1rVDEUhoModqwuXSqBbrrotfm6-QAplKG1xYIuVHAVMrnJNMOdZEzuLbQr_4P_0F_SDLeOHxsX5xwO5-HlvLwAvMToDUaKHofou1COV-GOcvwIzHBLRcM5po_BDCFCGiyV2gPPSlkhhBjl4inYo5goVMEZSGfeOzuEGxddKTB5-NHkIZgemtjB87Hv4WX0_ejinYFfjLUhmiGkCE_XKS7h_Dr0XXZ1XboOvoUKfnUmFxgivNje39d2BAnC-Of3H3Wo5-CJN31xLx7mPvh8fvZpftFcfXh3OT-9aiwTaGioE8rSlinlOVIOdx2imFLuiaolMGIE22oSiwVZyM5xLISSFHlHJbFC0H1wMuluxsXaddbFIZteb3JYm3yrkwn670sM13qZbjQXklT5KnD4IJDTt9GVQa9Dsa7vTXRpLJqQtmWcE7pFD_5BV2nMsdrThDHJGJIEVaqZKJtTKdn53TMY6W2UeopST1FW_vWfDnb0r-x-f5jGzX-1Xk3oqgwp72DCJVWtlPQeqhqxOw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2448440820</pqid></control><display><type>article</type><title>Effectiveness of Partial and Full Influenza Vaccination Among Children Aged < 9 Years in Hong Kong, 2011–2019</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Chua, Huiying ; Chiu, Susan S. ; Chan, Eunice L. Y. ; Feng, Shuo ; Kwan, Mike Y. W. ; Wong, Joshua S. C. ; Peiris, J. S. Malik ; Cowling, Benjamin J.</creator><creatorcontrib>Chua, Huiying ; Chiu, Susan S. ; Chan, Eunice L. Y. ; Feng, Shuo ; Kwan, Mike Y. W. ; Wong, Joshua S. C. ; Peiris, J. S. Malik ; Cowling, Benjamin J.</creatorcontrib><description>Abstract
Background
Two doses of influenza vaccination are recommended for previously unvaccinated children aged <9 years, and receipt of 1 dose is sometimes termed “partial vaccination.” We assessed the effectiveness of partial and full influenza vaccination in preventing influenza-associated hospitalization among children in Hong Kong.
Methods
Using the test-negative design we enrolled 23 187 children aged <9 years admitted to hospitals with acute respiratory illness from September 2011 through March 2019. Vaccination and influenza status were recorded. Fully vaccinated children included those vaccinated with 2 doses or, if previously vaccinated, those vaccinated with 1 dose. Partially vaccinated children included those who should have received 2 doses but only received 1 dose. We estimated vaccine effectiveness (VE) by using conditional logistic regression models matched on epidemiological week.
Results
Overall VE estimates among fully and partially vaccinated children were 73% (95% confidence interval, 69%–77%) and 31% (95% confidence interval, 8%–48%), respectively. A consistently higher VE was observed in children fully vaccinated against each influenza virus type/subtype. The effectiveness of partial vaccination did not vary by age group.
Conclusions
Partial vaccination was significantly less effective than full vaccination. Our study supports the current recommendation of 2 doses of influenza vaccination in previously unvaccinated children <9 years of age.
Full vaccination was significantly more protective than partial vaccination in preventing children 0.5–8 years of age against influenza-associated hospitalization, supporting the current Advisory Committee on Immunization Practices recommendation of a 2-dose regimen in previously unvaccinated children.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiz361</identifier><identifier>PMID: 31290537</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adolescent ; Child ; Child, Preschool ; Children ; Confidence intervals ; Epidemiology ; Female ; Hong Kong - epidemiology ; Hospitalization - statistics & numerical data ; Humans ; Immunization ; Infant ; Influenza ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Major and Brief Reports ; Male ; Regression analysis ; Treatment Outcome ; Vaccination ; Vaccine efficacy ; VACCINES</subject><ispartof>The Journal of infectious diseases, 2019-10, Vol.220 (10), p.1568-1576</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3e79c35499f609e1dd031336f296f2710421c61317b2b8de61779830fe382c773</citedby><cites>FETCH-LOGICAL-c470t-3e79c35499f609e1dd031336f296f2710421c61317b2b8de61779830fe382c773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31290537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chua, Huiying</creatorcontrib><creatorcontrib>Chiu, Susan S.</creatorcontrib><creatorcontrib>Chan, Eunice L. Y.</creatorcontrib><creatorcontrib>Feng, Shuo</creatorcontrib><creatorcontrib>Kwan, Mike Y. W.</creatorcontrib><creatorcontrib>Wong, Joshua S. C.</creatorcontrib><creatorcontrib>Peiris, J. S. Malik</creatorcontrib><creatorcontrib>Cowling, Benjamin J.</creatorcontrib><title>Effectiveness of Partial and Full Influenza Vaccination Among Children Aged < 9 Years in Hong Kong, 2011–2019</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
Two doses of influenza vaccination are recommended for previously unvaccinated children aged <9 years, and receipt of 1 dose is sometimes termed “partial vaccination.” We assessed the effectiveness of partial and full influenza vaccination in preventing influenza-associated hospitalization among children in Hong Kong.
Methods
Using the test-negative design we enrolled 23 187 children aged <9 years admitted to hospitals with acute respiratory illness from September 2011 through March 2019. Vaccination and influenza status were recorded. Fully vaccinated children included those vaccinated with 2 doses or, if previously vaccinated, those vaccinated with 1 dose. Partially vaccinated children included those who should have received 2 doses but only received 1 dose. We estimated vaccine effectiveness (VE) by using conditional logistic regression models matched on epidemiological week.
Results
Overall VE estimates among fully and partially vaccinated children were 73% (95% confidence interval, 69%–77%) and 31% (95% confidence interval, 8%–48%), respectively. A consistently higher VE was observed in children fully vaccinated against each influenza virus type/subtype. The effectiveness of partial vaccination did not vary by age group.
Conclusions
Partial vaccination was significantly less effective than full vaccination. Our study supports the current recommendation of 2 doses of influenza vaccination in previously unvaccinated children <9 years of age.
Full vaccination was significantly more protective than partial vaccination in preventing children 0.5–8 years of age against influenza-associated hospitalization, supporting the current Advisory Committee on Immunization Practices recommendation of a 2-dose regimen in previously unvaccinated children.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Confidence intervals</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hong Kong - epidemiology</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Influenza</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - prevention & control</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Regression analysis</subject><subject>Treatment Outcome</subject><subject>Vaccination</subject><subject>Vaccine efficacy</subject><subject>VACCINES</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rVDEUhoModqwuXSqBbrrotfm6-QAplKG1xYIuVHAVMrnJNMOdZEzuLbQr_4P_0F_SDLeOHxsX5xwO5-HlvLwAvMToDUaKHofou1COV-GOcvwIzHBLRcM5po_BDCFCGiyV2gPPSlkhhBjl4inYo5goVMEZSGfeOzuEGxddKTB5-NHkIZgemtjB87Hv4WX0_ejinYFfjLUhmiGkCE_XKS7h_Dr0XXZ1XboOvoUKfnUmFxgivNje39d2BAnC-Of3H3Wo5-CJN31xLx7mPvh8fvZpftFcfXh3OT-9aiwTaGioE8rSlinlOVIOdx2imFLuiaolMGIE22oSiwVZyM5xLISSFHlHJbFC0H1wMuluxsXaddbFIZteb3JYm3yrkwn670sM13qZbjQXklT5KnD4IJDTt9GVQa9Dsa7vTXRpLJqQtmWcE7pFD_5BV2nMsdrThDHJGJIEVaqZKJtTKdn53TMY6W2UeopST1FW_vWfDnb0r-x-f5jGzX-1Xk3oqgwp72DCJVWtlPQeqhqxOw</recordid><startdate>20191008</startdate><enddate>20191008</enddate><creator>Chua, Huiying</creator><creator>Chiu, Susan S.</creator><creator>Chan, Eunice L. Y.</creator><creator>Feng, Shuo</creator><creator>Kwan, Mike Y. W.</creator><creator>Wong, Joshua S. C.</creator><creator>Peiris, J. S. Malik</creator><creator>Cowling, Benjamin J.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191008</creationdate><title>Effectiveness of Partial and Full Influenza Vaccination Among Children Aged < 9 Years in Hong Kong, 2011–2019</title><author>Chua, Huiying ; Chiu, Susan S. ; Chan, Eunice L. Y. ; Feng, Shuo ; Kwan, Mike Y. W. ; Wong, Joshua S. C. ; Peiris, J. S. Malik ; Cowling, Benjamin J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3e79c35499f609e1dd031336f296f2710421c61317b2b8de61779830fe382c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Confidence intervals</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hong Kong - epidemiology</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Influenza</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - prevention & control</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Regression analysis</topic><topic>Treatment Outcome</topic><topic>Vaccination</topic><topic>Vaccine efficacy</topic><topic>VACCINES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chua, Huiying</creatorcontrib><creatorcontrib>Chiu, Susan S.</creatorcontrib><creatorcontrib>Chan, Eunice L. Y.</creatorcontrib><creatorcontrib>Feng, Shuo</creatorcontrib><creatorcontrib>Kwan, Mike Y. W.</creatorcontrib><creatorcontrib>Wong, Joshua S. C.</creatorcontrib><creatorcontrib>Peiris, J. S. Malik</creatorcontrib><creatorcontrib>Cowling, Benjamin J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chua, Huiying</au><au>Chiu, Susan S.</au><au>Chan, Eunice L. Y.</au><au>Feng, Shuo</au><au>Kwan, Mike Y. W.</au><au>Wong, Joshua S. C.</au><au>Peiris, J. S. Malik</au><au>Cowling, Benjamin J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Partial and Full Influenza Vaccination Among Children Aged < 9 Years in Hong Kong, 2011–2019</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2019-10-08</date><risdate>2019</risdate><volume>220</volume><issue>10</issue><spage>1568</spage><epage>1576</epage><pages>1568-1576</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
Two doses of influenza vaccination are recommended for previously unvaccinated children aged <9 years, and receipt of 1 dose is sometimes termed “partial vaccination.” We assessed the effectiveness of partial and full influenza vaccination in preventing influenza-associated hospitalization among children in Hong Kong.
Methods
Using the test-negative design we enrolled 23 187 children aged <9 years admitted to hospitals with acute respiratory illness from September 2011 through March 2019. Vaccination and influenza status were recorded. Fully vaccinated children included those vaccinated with 2 doses or, if previously vaccinated, those vaccinated with 1 dose. Partially vaccinated children included those who should have received 2 doses but only received 1 dose. We estimated vaccine effectiveness (VE) by using conditional logistic regression models matched on epidemiological week.
Results
Overall VE estimates among fully and partially vaccinated children were 73% (95% confidence interval, 69%–77%) and 31% (95% confidence interval, 8%–48%), respectively. A consistently higher VE was observed in children fully vaccinated against each influenza virus type/subtype. The effectiveness of partial vaccination did not vary by age group.
Conclusions
Partial vaccination was significantly less effective than full vaccination. Our study supports the current recommendation of 2 doses of influenza vaccination in previously unvaccinated children <9 years of age.
Full vaccination was significantly more protective than partial vaccination in preventing children 0.5–8 years of age against influenza-associated hospitalization, supporting the current Advisory Committee on Immunization Practices recommendation of a 2-dose regimen in previously unvaccinated children.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31290537</pmid><doi>10.1093/infdis/jiz361</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2019-10, Vol.220 (10), p.1568-1576 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Child Child, Preschool Children Confidence intervals Epidemiology Female Hong Kong - epidemiology Hospitalization - statistics & numerical data Humans Immunization Infant Influenza Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - epidemiology Influenza, Human - prevention & control Major and Brief Reports Male Regression analysis Treatment Outcome Vaccination Vaccine efficacy VACCINES |
| title | Effectiveness of Partial and Full Influenza Vaccination Among Children Aged < 9 Years in Hong Kong, 2011–2019 |
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