Genetic Signatures of Drug Response Variability in Drosophila melanogaster

Knowledge of the genetic basis underlying variation in response to environmental exposures or treatments is important in many research areas. For example, knowing the set of causal genetic variants for drug responses could revolutionize personalized medicine. We used to investigate the genetic signa...

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Veröffentlicht in:	Genetics (Austin) 2019-10, Vol.213 (2), p.633-650
Hauptverfasser:	Rohde, Palle Duun, Jensen, Iben Ravnborg, Sarup, Pernille Merete, Ørsted, Michael, Demontis, Ditte, Sørensen, Peter, Kristensen, Torsten Nygaard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animals Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Climate change Dopamine Drosophila melanogaster Drosophila melanogaster - drug effects Drosophila melanogaster - genetics Epigenetics Epistasis, Genetic - genetics Exposure Female Gene expression Gene Expression Regulation - drug effects Genes Genetic Association Studies Genetic diversity Genetic variance Genetic Variation - genetics Genetics Genome, Insect - drug effects Genomes Genomic analysis Genomics Genotypes Humans Hyperactivity Inbreeding Insects Investigations Knowledge Locomotion - drug effects Locomotion - genetics Locomotor activity Male Medical treatment Methylphenidate Methylphenidate - pharmacology Neurosciences Precision medicine Proteins Transcriptome - drug effects Transcriptome - genetics Variability
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