Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish

In larval zebrafish, melanocyte stem cells (MSCs) are quiescent, but can be recruited to regenerate the larval pigment pattern following melanocyte ablation. Through pharmacological experiments, we found that inhibition of γ-aminobutyric acid (GABA)-A receptor function, specifically the GABA-A ρ sub...

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Veröffentlicht in:	Genetics (Austin) 2019-10, Vol.213 (2), p.555-566
Hauptverfasser:	Allen, James R, Skeath, James B, Johnson, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Alleles Animals Cell Differentiation - genetics Cell division Cell Division - genetics CRISPR Danio rerio gamma-Aminobutyric Acid - genetics Genetics Homeostasis Investigations Kinases Larva - genetics Larva - growth & development Maintenance Melanocytes - metabolism Pharmacology Pigmentation - genetics Receptors Receptors, GABA-A - genetics Regeneration Regeneration - genetics Signal Transduction - genetics Signaling Stem cells Stem Cells - metabolism Transcription factors Zebrafish Zebrafish - genetics Zebrafish - growth & development Zebrafish Proteins - genetics
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