Prognostic value and association of Lauren classification with VEGF and VEGFR‑2 expression in gastric cancer
Gastric cancer (GC) is one of the most common malignant tumors in the world. As anti-angiogenic therapy shows efficacy in the treatment of GC, but only works in certain patients, the identification of potential beneficiaries are urgently required in order to apply appropriate treatments. The Lauren...
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| Veröffentlicht in: | Oncology letters 2019-11, Vol.18 (5), p.4891-4899 |
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| creator | Li, Xiayi Zhu, Xueru Wang, Yiwei Wang, Ruifen Wang, Lifeng Zhu, Mei-Ling Zheng, Leizhen |
| description | Gastric cancer (GC) is one of the most common malignant tumors in the world. As anti-angiogenic therapy shows efficacy in the treatment of GC, but only works in certain patients, the identification of potential beneficiaries are urgently required in order to apply appropriate treatments. The Lauren classification demonstrates numerous differences in etiology, epidemiology and pathology; however, the association between Lauren classification and pro-angiogenic factors remains unclear. The present study aimed to investigate the clinicopathological factors associated with Lauren classification and the prognostic significance of Lauren classification and vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) expression in GC. Paraffin-embedded GC tissues and clinical information of 255 patients with GC were collected. The clinicopathological factors associated with Lauren classification were evaluated by Logistic regression analysis. Kaplan-Meier survival and Cox regression analyses were used to examine the prognostic significance of Lauren classification and of VEGF and VEGFR-2 expression in patients with GC. The results demonstrated that there was no association between Lauren classification and VEGF and VEGFR-2 expression. Furthermore, results from survival analysis demonstrated that Lauren classification (P=0.001) and Tumor-Node-Metastasis stage (stage II, P=0.002; stage III, P |
| doi_str_mv | 10.3892/ol.2019.10820 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6781662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A605884869</galeid><sourcerecordid>A605884869</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-dada70f623c4c8e18122b647b1cd242e55f2c5a8dd16c59000b22f201fae7003</originalsourceid><addsrcrecordid>eNptkt9rHCEQx6W0NOGax74LhdKXvaq76-pLIYT8goOGEPoqnjveGTy96m7SvvVf6L_Yv6RuLqS5En1wHD_zHWYchN5TMq-FZJ-jnzNC5ZwSwcgrdEg7yarp8vrJ7poDdJTzLSmr5VQI_hYd1JRTKqU8ROEqxVWIeXAG32k_AtahxzrnaJweXAw4WrzQY4KAjS9-Z53ZPdy7YY2_nZ6fPYRMxvWfX78Zhh_bBAUsiAt4pfOQirjRwUB6h95Y7TMcPZ4zdHN2enNyUS2-nl-eHC8q00gyVL3udUcsZ7VpjAAqKGNL3nRLanrWMGhby0yrRd9TblpZSlsyZksrrIaOkHqGvuxkt-NyA72BMCTt1Ta5jU4_VdRO7b8Et1areKd4JygvaWfo06NAit9HyIPauGzAex0gjlmxmrSdLO2sC_rhP_Q2jimU6gpFCWesqbt_1Ep7UC7YWPKaSVQdc9IK0QguCzV_gSq7h40zMYB1xb8X8PFZwBq0H9Y5-nH6oLwPVjvQpJhzAvvUDErUNEsqejXNknqYpfovR5e5vg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2310622437</pqid></control><display><type>article</type><title>Prognostic value and association of Lauren classification with VEGF and VEGFR‑2 expression in gastric cancer</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Li, Xiayi ; Zhu, Xueru ; Wang, Yiwei ; Wang, Ruifen ; Wang, Lifeng ; Zhu, Mei-Ling ; Zheng, Leizhen</creator><creatorcontrib>Li, Xiayi ; Zhu, Xueru ; Wang, Yiwei ; Wang, Ruifen ; Wang, Lifeng ; Zhu, Mei-Ling ; Zheng, Leizhen</creatorcontrib><description>Gastric cancer (GC) is one of the most common malignant tumors in the world. As anti-angiogenic therapy shows efficacy in the treatment of GC, but only works in certain patients, the identification of potential beneficiaries are urgently required in order to apply appropriate treatments. The Lauren classification demonstrates numerous differences in etiology, epidemiology and pathology; however, the association between Lauren classification and pro-angiogenic factors remains unclear. The present study aimed to investigate the clinicopathological factors associated with Lauren classification and the prognostic significance of Lauren classification and vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) expression in GC. Paraffin-embedded GC tissues and clinical information of 255 patients with GC were collected. The clinicopathological factors associated with Lauren classification were evaluated by Logistic regression analysis. Kaplan-Meier survival and Cox regression analyses were used to examine the prognostic significance of Lauren classification and of VEGF and VEGFR-2 expression in patients with GC. The results demonstrated that there was no association between Lauren classification and VEGF and VEGFR-2 expression. Furthermore, results from survival analysis demonstrated that Lauren classification (P=0.001) and Tumor-Node-Metastasis stage (stage II, P=0.002; stage III, P<0.001) were independent prognostic factors in GC. Following subgroup analysis based on Tumor-Node-Metastasis stage, Lauren classification was demonstrated to be an independent prognostic factor in patients with stage III GC (P=0.010) but not in patients with stage I or II GC. Furthermore, VEGFR-2 overexpression was an independent predictor of survival in intestinal-type GC (P=0.040) but not in diffuse-type GC. Taken together, these results indicate that Lauren classification may serve as an independent prognostic factor for patients cwith GC. In addition, although the expression of VEGF and VEGFR-2 was not associated with Lauren classification, VEGFR-2 overexpression may be considered as an independent prognostic factor in intestinal-type GC. Key words: gastric cancer, Lauren classification, prognosis, vascular endothelial growth factor, vascular endothelial growth factor receptor-2</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2019.10820</identifier><identifier>PMID: 31611999</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Analysis ; Angiogenesis ; Beneficiaries ; Cancer ; Cancer metastasis ; Cancer therapies ; Chemotherapy ; Classification ; Confidence intervals ; Development and progression ; Endothelial growth factors ; Endothelium ; Epidemiology ; Ethanol ; Etiology (Medicine) ; Family medical history ; Gastric cancer ; Medical prognosis ; Medical schools ; Metastasis ; Multivariate analysis ; Oncology ; Regression analysis ; Stomach cancer ; Tumors ; Vascular endothelial growth factor</subject><ispartof>Oncology letters, 2019-11, Vol.18 (5), p.4891-4899</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Li et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-dada70f623c4c8e18122b647b1cd242e55f2c5a8dd16c59000b22f201fae7003</citedby><cites>FETCH-LOGICAL-c490t-dada70f623c4c8e18122b647b1cd242e55f2c5a8dd16c59000b22f201fae7003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781662/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781662/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids></links><search><creatorcontrib>Li, Xiayi</creatorcontrib><creatorcontrib>Zhu, Xueru</creatorcontrib><creatorcontrib>Wang, Yiwei</creatorcontrib><creatorcontrib>Wang, Ruifen</creatorcontrib><creatorcontrib>Wang, Lifeng</creatorcontrib><creatorcontrib>Zhu, Mei-Ling</creatorcontrib><creatorcontrib>Zheng, Leizhen</creatorcontrib><title>Prognostic value and association of Lauren classification with VEGF and VEGFR‑2 expression in gastric cancer</title><title>Oncology letters</title><description>Gastric cancer (GC) is one of the most common malignant tumors in the world. As anti-angiogenic therapy shows efficacy in the treatment of GC, but only works in certain patients, the identification of potential beneficiaries are urgently required in order to apply appropriate treatments. The Lauren classification demonstrates numerous differences in etiology, epidemiology and pathology; however, the association between Lauren classification and pro-angiogenic factors remains unclear. The present study aimed to investigate the clinicopathological factors associated with Lauren classification and the prognostic significance of Lauren classification and vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) expression in GC. Paraffin-embedded GC tissues and clinical information of 255 patients with GC were collected. The clinicopathological factors associated with Lauren classification were evaluated by Logistic regression analysis. Kaplan-Meier survival and Cox regression analyses were used to examine the prognostic significance of Lauren classification and of VEGF and VEGFR-2 expression in patients with GC. The results demonstrated that there was no association between Lauren classification and VEGF and VEGFR-2 expression. Furthermore, results from survival analysis demonstrated that Lauren classification (P=0.001) and Tumor-Node-Metastasis stage (stage II, P=0.002; stage III, P<0.001) were independent prognostic factors in GC. Following subgroup analysis based on Tumor-Node-Metastasis stage, Lauren classification was demonstrated to be an independent prognostic factor in patients with stage III GC (P=0.010) but not in patients with stage I or II GC. Furthermore, VEGFR-2 overexpression was an independent predictor of survival in intestinal-type GC (P=0.040) but not in diffuse-type GC. Taken together, these results indicate that Lauren classification may serve as an independent prognostic factor for patients cwith GC. In addition, although the expression of VEGF and VEGFR-2 was not associated with Lauren classification, VEGFR-2 overexpression may be considered as an independent prognostic factor in intestinal-type GC. Key words: gastric cancer, Lauren classification, prognosis, vascular endothelial growth factor, vascular endothelial growth factor receptor-2</description><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Beneficiaries</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Classification</subject><subject>Confidence intervals</subject><subject>Development and progression</subject><subject>Endothelial growth factors</subject><subject>Endothelium</subject><subject>Epidemiology</subject><subject>Ethanol</subject><subject>Etiology (Medicine)</subject><subject>Family medical history</subject><subject>Gastric cancer</subject><subject>Medical prognosis</subject><subject>Medical schools</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Regression analysis</subject><subject>Stomach cancer</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt9rHCEQx6W0NOGax74LhdKXvaq76-pLIYT8goOGEPoqnjveGTy96m7SvvVf6L_Yv6RuLqS5En1wHD_zHWYchN5TMq-FZJ-jnzNC5ZwSwcgrdEg7yarp8vrJ7poDdJTzLSmr5VQI_hYd1JRTKqU8ROEqxVWIeXAG32k_AtahxzrnaJweXAw4WrzQY4KAjS9-Z53ZPdy7YY2_nZ6fPYRMxvWfX78Zhh_bBAUsiAt4pfOQirjRwUB6h95Y7TMcPZ4zdHN2enNyUS2-nl-eHC8q00gyVL3udUcsZ7VpjAAqKGNL3nRLanrWMGhby0yrRd9TblpZSlsyZksrrIaOkHqGvuxkt-NyA72BMCTt1Ta5jU4_VdRO7b8Et1areKd4JygvaWfo06NAit9HyIPauGzAex0gjlmxmrSdLO2sC_rhP_Q2jimU6gpFCWesqbt_1Ep7UC7YWPKaSVQdc9IK0QguCzV_gSq7h40zMYB1xb8X8PFZwBq0H9Y5-nH6oLwPVjvQpJhzAvvUDErUNEsqejXNknqYpfovR5e5vg</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Li, Xiayi</creator><creator>Zhu, Xueru</creator><creator>Wang, Yiwei</creator><creator>Wang, Ruifen</creator><creator>Wang, Lifeng</creator><creator>Zhu, Mei-Ling</creator><creator>Zheng, Leizhen</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191101</creationdate><title>Prognostic value and association of Lauren classification with VEGF and VEGFR‑2 expression in gastric cancer</title><author>Li, Xiayi ; Zhu, Xueru ; Wang, Yiwei ; Wang, Ruifen ; Wang, Lifeng ; Zhu, Mei-Ling ; Zheng, Leizhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-dada70f623c4c8e18122b647b1cd242e55f2c5a8dd16c59000b22f201fae7003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Angiogenesis</topic><topic>Beneficiaries</topic><topic>Cancer</topic><topic>Cancer metastasis</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Classification</topic><topic>Confidence intervals</topic><topic>Development and progression</topic><topic>Endothelial growth factors</topic><topic>Endothelium</topic><topic>Epidemiology</topic><topic>Ethanol</topic><topic>Etiology (Medicine)</topic><topic>Family medical history</topic><topic>Gastric cancer</topic><topic>Medical prognosis</topic><topic>Medical schools</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Regression analysis</topic><topic>Stomach cancer</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiayi</creatorcontrib><creatorcontrib>Zhu, Xueru</creatorcontrib><creatorcontrib>Wang, Yiwei</creatorcontrib><creatorcontrib>Wang, Ruifen</creatorcontrib><creatorcontrib>Wang, Lifeng</creatorcontrib><creatorcontrib>Zhu, Mei-Ling</creatorcontrib><creatorcontrib>Zheng, Leizhen</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiayi</au><au>Zhu, Xueru</au><au>Wang, Yiwei</au><au>Wang, Ruifen</au><au>Wang, Lifeng</au><au>Zhu, Mei-Ling</au><au>Zheng, Leizhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value and association of Lauren classification with VEGF and VEGFR‑2 expression in gastric cancer</atitle><jtitle>Oncology letters</jtitle><date>2019-11-01</date><risdate>2019</risdate><volume>18</volume><issue>5</issue><spage>4891</spage><epage>4899</epage><pages>4891-4899</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Gastric cancer (GC) is one of the most common malignant tumors in the world. As anti-angiogenic therapy shows efficacy in the treatment of GC, but only works in certain patients, the identification of potential beneficiaries are urgently required in order to apply appropriate treatments. The Lauren classification demonstrates numerous differences in etiology, epidemiology and pathology; however, the association between Lauren classification and pro-angiogenic factors remains unclear. The present study aimed to investigate the clinicopathological factors associated with Lauren classification and the prognostic significance of Lauren classification and vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) expression in GC. Paraffin-embedded GC tissues and clinical information of 255 patients with GC were collected. The clinicopathological factors associated with Lauren classification were evaluated by Logistic regression analysis. Kaplan-Meier survival and Cox regression analyses were used to examine the prognostic significance of Lauren classification and of VEGF and VEGFR-2 expression in patients with GC. The results demonstrated that there was no association between Lauren classification and VEGF and VEGFR-2 expression. Furthermore, results from survival analysis demonstrated that Lauren classification (P=0.001) and Tumor-Node-Metastasis stage (stage II, P=0.002; stage III, P<0.001) were independent prognostic factors in GC. Following subgroup analysis based on Tumor-Node-Metastasis stage, Lauren classification was demonstrated to be an independent prognostic factor in patients with stage III GC (P=0.010) but not in patients with stage I or II GC. Furthermore, VEGFR-2 overexpression was an independent predictor of survival in intestinal-type GC (P=0.040) but not in diffuse-type GC. Taken together, these results indicate that Lauren classification may serve as an independent prognostic factor for patients cwith GC. In addition, although the expression of VEGF and VEGFR-2 was not associated with Lauren classification, VEGFR-2 overexpression may be considered as an independent prognostic factor in intestinal-type GC. Key words: gastric cancer, Lauren classification, prognosis, vascular endothelial growth factor, vascular endothelial growth factor receptor-2</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>31611999</pmid><doi>10.3892/ol.2019.10820</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Angiogenesis Beneficiaries Cancer Cancer metastasis Cancer therapies Chemotherapy Classification Confidence intervals Development and progression Endothelial growth factors Endothelium Epidemiology Ethanol Etiology (Medicine) Family medical history Gastric cancer Medical prognosis Medical schools Metastasis Multivariate analysis Oncology Regression analysis Stomach cancer Tumors Vascular endothelial growth factor |
| title | Prognostic value and association of Lauren classification with VEGF and VEGFR‑2 expression in gastric cancer |
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