Disparate effects of cytotoxic chemotherapy on the antiviral activity of antiretroviral therapy: implications for treatments of HIV-infected cancer patients

Cancer is a leading cause of death in HIV-infected patients in the era of combination antiretroviral therapy (cART). Yet, there are no specific guidelines for the combined use of cART and chemotherapy in HIV-infected cancer patients. The cellular enzyme thymidylate synthase (TS) catalyses the conver...

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Veröffentlicht in:	Antiviral therapy 2019-01, Vol.24 (3), p.177-186
Hauptverfasser:	Medina-Moreno, Sandra, Zapata, Juan C, Cottrell, Mackenzie L, Le, Nhut M, Tao, Sijia, Bryant, Joseph, Sausville, Edward, Schinazi, Raymond F, Kashuba, Angela Dm, Redfield, Robert R, Heredia, Alonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Abacavir Animals Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - methods Antiviral activity Biomarkers Cancer therapies CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Chemotherapy Cytotoxicity Disease Models, Animal DNA biosynthesis Drug Interactions Drug therapy Emtricitabine Female Gemcitabine HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus Humans Infectivity Lamivudine Leukocytes (mononuclear) Male Metabolites Mice Mice, Transgenic Neoplasms - complications Neoplasms - drug therapy Non-small cell lung carcinoma Nucleoside analogs Peripheral blood mononuclear cells RNA-directed DNA polymerase Tenofovir Thymidylate synthase Treatment Outcome Viral Load
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