Comprehensive immune characterization and T‐cell receptor repertoire heterogeneity of retroperitoneal liposarcoma

Retroperitoneal liposarcoma (RLPS) is one of the most common subtypes of retroperitoneal soft tissue sarcomas and lacks effective treatment. This study aimed to provide a thorough profile of immune characteristics of RLPS. This study included 56 RLPS patients. Multisite tumor tissues were collected...

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Veröffentlicht in:	Cancer science 2019-10, Vol.110 (10), p.3038-3048
Hauptverfasser:	Yan, Liang, Wang, Zhen, Cui, Can, Guan, Xiaoya, Dong, Bin, Zhao, Min, Wu, Jianhui, Tian, Xiuyun, Hao, Chunyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Algorithms Antigens Apoptosis B-Lymphocytes - immunology B7-H1 Antigen - metabolism Cancer therapies CD20 antigen CD4 antigen CD8 antigen Cell death Cell survival Chemotherapy Cloning Deoxyribonucleic acid Disease-Free Survival DNA Down-Regulation Female Foxp3 protein Gene expression Gene Expression Regulation, Neoplastic heterogeneity High-Throughput Nucleotide Sequencing - methods Hospitals Humans immune landscape Immune system Immunohistochemistry Immunotherapy Infiltration Liposarcoma Liposarcoma - genetics Liposarcoma - immunology Liposarcoma - mortality Lymphocytes Lymphocytes B Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Male Medical prognosis Metastases Middle Aged Original PD-1 protein PD-L1 protein Peripheral blood Prognosis Programmed Cell Death 1 Receptor - metabolism Radiation therapy Receptors, Antigen, T-Cell, alpha-beta - genetics retroperitoneal liposarcoma Retroperitoneal Neoplasms - genetics Retroperitoneal Neoplasms - immunology Retroperitoneal Neoplasms - mortality Sample size Sarcoma Sequence Analysis, DNA Studies T cell receptors T-Lymphocytes - immunology Tumors Tumor‐infiltrating lymphocytes (TILs) T‐cell receptor Up-Regulation
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