CryoEM maps are full of potential

•Maps derived by X-ray crystallography display electron density, whereas maps derived by electron microscopy display Coulomb potential.•Negatively charged oxygen can result in attenuated positive potentials and even regions of negative density or ‘holes’ in Coulomb potential maps.•Biological molecul...

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Veröffentlicht in:	Current opinion in structural biology 2019-10, Vol.58, p.214-223
Hauptverfasser:	Marques, Mayra A, Purdy, Michael D, Yeager, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Cryoelectron Microscopy - methods Oxygen - chemistry Proteins - chemistry
Online-Zugang:	Volltext
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