The gut microbiome regulates host glucose homeostasis via peripheral serotonin
The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis,...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2019-10, Vol.116 (40), p.19802-19804 |
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| container_issue | 40 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 116 |
| creator | Martin, Alyce M. Yabut, Julian M. Choo, Jocelyn M. Page, Amanda J. Sun, Emily W. Jessup, Claire F. Wesselingh, Steve L. Khan, Waliul I. Rogers, Geraint B. Steinberg, Gregory R. Keating, Damien J. |
| description | The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. Using both pharmacological inhibition and genetic deletion of gut-derived serotonin synthesis, we find that the improvements in host glucose handling caused by antibiotic-induced changes in microbiota composition are dependent on the synthesis of peripheral serotonin. |
| doi_str_mv | 10.1073/pnas.1909311116 |
| format | Article |
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Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. 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Published by PNAS.</rights><rights>Copyright National Academy of Sciences Oct 1, 2019</rights><rights>Copyright © 2019 the Author(s). 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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (40), p.19802-19804 |
| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotics Area Under Curve Biological Sciences Blood Glucose - metabolism BRIEF REPORTS Gastrointestinal Microbiome Gene Deletion Glucose Glucose - metabolism Glucose Tolerance Test Homeostasis Intestinal microflora Male Mice Mice, Inbred C57BL Microbiomes Microbiota Random Allocation Serotonin Serotonin - physiology Synthesis |
| title | The gut microbiome regulates host glucose homeostasis via peripheral serotonin |
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