Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

Although olfactory mucosa possesses long-lived horizontal basal stem cells (HBCs) and remarkable regenerative capacity, the function of human olfactory neuroepithelium is significantly impaired in chronic inflammatory rhinosinusitis. Here, we show that, while inflammation initially damages olfactory...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell stem cell 2019-10, Vol.25 (4), p.501-513.e5
Hauptverfasser:	Chen, Mengfei, Reed, Randall R., Lane, Andrew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basal stem cell Cell Differentiation Cell Proliferation Cell Self Renewal - genetics Cells, Cultured chemokine Chronic Disease chronic inflammation Humans Immunity Inflammation - immunology Mice Mice, Transgenic neural stem cell neurogenesis Neurons - physiology NF-kappa B - metabolism NF-kB olfactory epithelium Olfactory Mucosa - physiology Regeneration Rhinitis - immunology Sinusitis - immunology Stem Cells - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!