Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

N6-methyladenosine (m6A) modification occurs co-transcriptionally and impacts pre-mRNA processing; however, the mechanism of co-transcriptional m6A-dependent alternative splicing regulation is still poorly understood. Heterogeneous nuclear ribonucleoprotein G (hnRNPG) is an m6A reader protein that b...

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Veröffentlicht in:	Molecular cell 2019-10, Vol.76 (1), p.70-81.e9
Hauptverfasser:	Zhou, Katherine I., Shi, Hailing, Lyu, Ruitu, Wylder, Adam C., Matuszek, Żaneta, Pan, Jessica N., He, Chuan, Parisien, Marc, Pan, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative splicing co-transcription CTD domain DNA-directed RNA polymerase exons hnRNPG low complexity region m6A RBMX RGG ribonucleoproteins RNA RNA polymerase II splicing
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