Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway

Biliary cancer (BC) is an aggressive neoplasm with high mortality. BC can be categorized into three groups: Intrahepatic cholangiocarcinoma (CCA; also known as bile duct cancer), extrahepatic cholangiocarcinoma and gallbladder cancer. Due to its heterogeneity and aggressiveness, the response to curr...

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Veröffentlicht in:	International journal of molecular medicine 2019-11, Vol.44 (5), p.1687-1696
Hauptverfasser:	Chen, San-Yuan, Huang, Hsin-Yi, Lin, Han-Pei, Fang, Chiung-Yao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - metabolism Antineoplastic Agents - pharmacology Antioxidants Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biliary tract cancer Breast cancer Canada Cancer Cancer cells Cancer therapies Cancer treatment Cell cycle Cell Cycle Checkpoints - drug effects Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Cholangiocarcinoma Cyclin-dependent kinases Cysteine Cystine Cytotoxicity Dioxolanes - pharmacology Drugs G1 Phase - drug effects Gallbladder Gallbladder cancer Germany Health aspects Humans Immunoglobulins Kinases MAP Kinase Signaling System - drug effects Mortality Pharmaceutical industry Prostate Proteins Radiotherapy Reactive oxygen species Reactive Oxygen Species - metabolism Resting Phase, Cell Cycle - drug effects Scientific equipment industry Signal Transduction - drug effects Studies Tumors United States
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