Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability

Blood–brain barrier (BBB) disruption in neurological disorders remains an intractable problem with limited therapeutic options. Here, we investigate whether the endothelial cell membrane protein annexin A2 (ANXA2) may play a role in reducing trans-endothelial permeability and maintaining cerebrovasc...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2019-10, Vol.39 (10), p.2048-2060
Hauptverfasser:	Li, Wenlu, Chen, Zhigang, Yuan, Jing, Yu, Zhanyang, Cheng, Chongjie, Zhao, Qiuchen, Huang, Lena, Hajjar, Katherine A, Chen, Zhong, Lo, Eng H, Dai, Haibin, Wang, Xiaoying
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - metabolism Animals Annexin A2 - genetics Annexin A2 - metabolism Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Capillary Permeability Cell Hypoxia Cell Line Endothelial Cells - metabolism Endothelial Cells - pathology Humans Mice Mice, Knockout Original Receptors, Cell Surface - metabolism
Online-Zugang:	Volltext
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