Efficacy and safety of lactulose for the treatment of irritable bowel syndrome
In this study, investigators will evaluate the efficacy and safety of lactulose for the treatment of irritable bowel syndrome (IBS). Literature search for relevant studies up to present will be conducted in MEDICINE, EMBASE, Google Scholar, Web of Science, Cochrane Library, Wangfang, Allied and Comp...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-09, Vol.98 (39), p.e17295-e17295 |
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| creator | Chen, Hong-Bin Su, Xiao-Ying |
| description | In this study, investigators will evaluate the efficacy and safety of lactulose for the treatment of irritable bowel syndrome (IBS).
Literature search for relevant studies up to present will be conducted in MEDICINE, EMBASE, Google Scholar, Web of Science, Cochrane Library, Wangfang, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. The included studies are randomized controlled trials of lactulose in patients with IBS. We will use RevMan 5.3 software using statistical analysis.
This study will provide a high-quality integration of current evidence of lactulose for treating IBS on several aspects including global IBS symptoms, abdominal pain, defecation urgency, stool frequency, stool consistency, quality of life, and adverse events.
This study will provide the evidence for the clinical efficacy and safety of lactulose for the treatment of IBS.
PROSPERO CRD42019140639. |
| doi_str_mv | 10.1097/MD.0000000000017295 |
| format | Article |
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Literature search for relevant studies up to present will be conducted in MEDICINE, EMBASE, Google Scholar, Web of Science, Cochrane Library, Wangfang, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. The included studies are randomized controlled trials of lactulose in patients with IBS. We will use RevMan 5.3 software using statistical analysis.
This study will provide a high-quality integration of current evidence of lactulose for treating IBS on several aspects including global IBS symptoms, abdominal pain, defecation urgency, stool frequency, stool consistency, quality of life, and adverse events.
This study will provide the evidence for the clinical efficacy and safety of lactulose for the treatment of IBS.
PROSPERO CRD42019140639.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000017295</identifier><identifier>PMID: 31574851</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health</publisher><subject>Gastrointestinal Agents - therapeutic use ; Humans ; Irritable Bowel Syndrome - drug therapy ; Lactulose - therapeutic use ; Randomized Controlled Trials as Topic ; Research Design ; Study Protocol Systematic Review ; Systematic Reviews as Topic ; Treatment Outcome</subject><ispartof>Medicine (Baltimore), 2019-09, Vol.98 (39), p.e17295-e17295</ispartof><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-4859ed7742db9e000350c62f2ca3958ffd08045fddb052469bb1c2497b249d063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775399/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775399/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31574851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hong-Bin</creatorcontrib><creatorcontrib>Su, Xiao-Ying</creatorcontrib><title>Efficacy and safety of lactulose for the treatment of irritable bowel syndrome</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>In this study, investigators will evaluate the efficacy and safety of lactulose for the treatment of irritable bowel syndrome (IBS).
Literature search for relevant studies up to present will be conducted in MEDICINE, EMBASE, Google Scholar, Web of Science, Cochrane Library, Wangfang, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. The included studies are randomized controlled trials of lactulose in patients with IBS. We will use RevMan 5.3 software using statistical analysis.
This study will provide a high-quality integration of current evidence of lactulose for treating IBS on several aspects including global IBS symptoms, abdominal pain, defecation urgency, stool frequency, stool consistency, quality of life, and adverse events.
This study will provide the evidence for the clinical efficacy and safety of lactulose for the treatment of IBS.
PROSPERO CRD42019140639.</description><subject>Gastrointestinal Agents - therapeutic use</subject><subject>Humans</subject><subject>Irritable Bowel Syndrome - drug therapy</subject><subject>Lactulose - therapeutic use</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Research Design</subject><subject>Study Protocol Systematic Review</subject><subject>Systematic Reviews as Topic</subject><subject>Treatment Outcome</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUMlOwzAUtBCIlsIXICEfuaR4ieP4goRKWaQCFzhHjhcalMTFdkD5e4wo2zvMO8xoZjQAHGM0x0jws7vLOfo9zIlgO2CKGS0yJop8F0wRIizjgucTcBDCSxJRTvJ9MKGY8bxkeArul9Y2SqoRyl7DIK2JI3QWtlLFoXXBQOs8jGsDozcydqaPn3TjfRNl3RpYu3fTwjD22rvOHII9K9tgjrZ_Bp6ulo-Lm2z1cH27uFhlihY4ZilbGM15TnQtTGpPGVIFsURJKlhprUYlypnVukaM5IWoa6xILnidQKOCzsD5l-9mqDujVarlZVttfNNJP1ZONtV_pm_W1bN7qwrOGRUiGZxuDbx7HUyIVdcEZdpW9sYNoSI0rZUWYmWSnvzN-gn5HpF-AHLNdWE</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Chen, Hong-Bin</creator><creator>Su, Xiao-Ying</creator><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>Efficacy and safety of lactulose for the treatment of irritable bowel syndrome</title><author>Chen, Hong-Bin ; Su, Xiao-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-4859ed7742db9e000350c62f2ca3958ffd08045fddb052469bb1c2497b249d063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Gastrointestinal Agents - therapeutic use</topic><topic>Humans</topic><topic>Irritable Bowel Syndrome - drug therapy</topic><topic>Lactulose - therapeutic use</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Research Design</topic><topic>Study Protocol Systematic Review</topic><topic>Systematic Reviews as Topic</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hong-Bin</creatorcontrib><creatorcontrib>Su, Xiao-Ying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hong-Bin</au><au>Su, Xiao-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and safety of lactulose for the treatment of irritable bowel syndrome</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>98</volume><issue>39</issue><spage>e17295</spage><epage>e17295</epage><pages>e17295-e17295</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>In this study, investigators will evaluate the efficacy and safety of lactulose for the treatment of irritable bowel syndrome (IBS).
Literature search for relevant studies up to present will be conducted in MEDICINE, EMBASE, Google Scholar, Web of Science, Cochrane Library, Wangfang, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. The included studies are randomized controlled trials of lactulose in patients with IBS. We will use RevMan 5.3 software using statistical analysis.
This study will provide a high-quality integration of current evidence of lactulose for treating IBS on several aspects including global IBS symptoms, abdominal pain, defecation urgency, stool frequency, stool consistency, quality of life, and adverse events.
This study will provide the evidence for the clinical efficacy and safety of lactulose for the treatment of IBS.
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| identifier | ISSN: 0025-7974 |
| ispartof | Medicine (Baltimore), 2019-09, Vol.98 (39), p.e17295-e17295 |
| issn | 0025-7974 1536-5964 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Gastrointestinal Agents - therapeutic use Humans Irritable Bowel Syndrome - drug therapy Lactulose - therapeutic use Randomized Controlled Trials as Topic Research Design Study Protocol Systematic Review Systematic Reviews as Topic Treatment Outcome |
| title | Efficacy and safety of lactulose for the treatment of irritable bowel syndrome |
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