Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor

Breast cancer cells experience a range of shear stresses in the tumor microenvironment (TME). However most current in vitro three‐dimensional (3D) models fail to systematically probe the effects of this biophysical stimuli on cancer cell metastasis, proliferation, and chemoresistance. To investigate...

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Veröffentlicht in:	Biotechnology and bioengineering 2019-11, Vol.116 (11), p.3084-3097
Hauptverfasser:	Novak, Caymen M., Horst, Eric N., Taylor, Charles C., Liu, Catherine Z., Mehta, Geeta
Format:	Artikel
Sprache:	eng
Schlagworte:	3D bioreactor Bioreactors Breast cancer Cell proliferation Chemoresistance Extracellular matrix Finite element method Fluid flow Hydrogels interpenetrating hydrogel Invasiveness Mathematical models Mechanical stimuli mechanotransduction Metastases Paclitaxel Phenotypes PLAU Pleural effusion Shear stress Three dimensional models U-Plasminogen activator Urokinase
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