Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments

( ) is among the most common genes mutated in autism spectrum disorders (ASD) and is the causative gene in Phelan-McDermid syndrome (PMS). We performed genetic rescue of mutant phenotypes in adult mice expressing a exon 21 insertion mutation ( ). We used a tamoxifen-inducible Cre/loxP system ( ) to...

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