The effect of high glucose on lipid metabolism in the human placenta

Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Pl...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.14114-9, Article 14114
Hauptverfasser:	Hulme, Charlotte H., Nicolaou, Anna, Murphy, Sharon A., Heazell, Alexander E. P., Myers, Jenny E., Westwood, Melissa
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 14/63 692/699/2732 692/699/2743 82/80 Adult Birth Weight - physiology Diabetes mellitus Diabetes, Gestational - metabolism Explants Fatty acids Fatty Acids - metabolism Female Fetus - metabolism Fetuses Glucose Glucose - metabolism Humanities and Social Sciences Humans Hyperglycemia Lipase Lipid metabolism Lipid Metabolism - physiology Lipids Lipoprotein Lipase - metabolism Metabolism multidisciplinary Obesity - metabolism Oxidation Oxidation-Reduction Placenta Placenta - metabolism Pregnancy Pregnancy in Diabetics - metabolism Science Science (multidisciplinary) Triglycerides - metabolism Young Adult
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