Impaired Recognition Memory in Rats after Damage to the Hippocampus
Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All oper...
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| Veröffentlicht in: | The Journal of neuroscience 2000-12, Vol.20 (23), p.8853-8860 |
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| creator | Clark, Robert E Zola, Stuart M Squire, Larry R |
| description | Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. The findings are discussed in the context of the contribution of the hippocampus to recognition memory. |
| doi_str_mv | 10.1523/jneurosci.20-23-08853.2000 |
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Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. 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Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. The findings are discussed in the context of the contribution of the hippocampus to recognition memory.</description><subject>Animals</subject><subject>Catheter Ablation</subject><subject>Fornix, Brain - pathology</subject><subject>Fornix, Brain - physiology</subject><subject>Fornix, Brain - surgery</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiology</subject><subject>Hippocampus - surgery</subject><subject>Ibotenic Acid - pharmacology</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Pattern Recognition, Visual - drug effects</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Recognition (Psychology) - physiology</subject><subject>Research Design</subject><subject>Sensitivity and Specificity</subject><subject>Spatial Behavior - drug effects</subject><subject>Spatial Behavior - physiology</subject><subject>Time Factors</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1v0zAUhi0EYmXwF1DEBVxlHH_FKRdIqAxWNJhU2LXlOMetpyTO7IRq_x6XVnxc2Zaf89h6X0JeUbigkvG3dwPOMSTrLxiUjJdQ15LnPcAjssjEsmQC6GOyAKagrIQSZ-RZSncZUEDVU3JGKQUmlmJBVut-ND5iW2zQhu3gJx-G4iv2IT4Ufig2ZkqFcRPG4qPpzRaLKRTTDosrP47Bmn6c03PyxJku4YvTek5uP13-WF2V1zef16sP16WVSk0lrVApkA2CaQVwVjetQSsla5rW1YYD2IoJ4Worl5Y67lQlG9egYLxZutrxc_L-6B3npsfW4jBF0-kx-t7EBx2M1__fDH6nt-GnrpTiIGUWvD4JYrifMU2698li15kBw5y0YkLSnEsG3x1Bm3NOEd2fRyjoQwf6y7fL283N99VaM9D5_LsDfeggD7_895t_R0-hZ-DNEdj57W6fw9epN12Xcar3-_1RePDxXzZJk_U</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Clark, Robert E</creator><creator>Zola, Stuart M</creator><creator>Squire, Larry R</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20001201</creationdate><title>Impaired Recognition Memory in Rats after Damage to the Hippocampus</title><author>Clark, Robert E ; Zola, Stuart M ; Squire, Larry R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-16e7705be0ad40328bdaec552bbdf8a300c6244f8c59c1f3f765bfbe423b9f8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Catheter Ablation</topic><topic>Fornix, Brain - pathology</topic><topic>Fornix, Brain - physiology</topic><topic>Fornix, Brain - surgery</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiology</topic><topic>Hippocampus - surgery</topic><topic>Ibotenic Acid - pharmacology</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Pattern Recognition, Visual - drug effects</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Recognition (Psychology) - physiology</topic><topic>Research Design</topic><topic>Sensitivity and Specificity</topic><topic>Spatial Behavior - drug effects</topic><topic>Spatial Behavior - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clark, Robert E</creatorcontrib><creatorcontrib>Zola, Stuart M</creatorcontrib><creatorcontrib>Squire, Larry R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clark, Robert E</au><au>Zola, Stuart M</au><au>Squire, Larry R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Recognition Memory in Rats after Damage to the Hippocampus</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>20</volume><issue>23</issue><spage>8853</spage><epage>8860</epage><pages>8853-8860</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. The findings are discussed in the context of the contribution of the hippocampus to recognition memory.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>11102494</pmid><doi>10.1523/jneurosci.20-23-08853.2000</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Catheter Ablation Fornix, Brain - pathology Fornix, Brain - physiology Fornix, Brain - surgery Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiology Hippocampus - surgery Ibotenic Acid - pharmacology Male Memory - drug effects Memory - physiology Pattern Recognition, Visual - drug effects Pattern Recognition, Visual - physiology Rats Rats, Long-Evans Reaction Time - drug effects Reaction Time - physiology Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Research Design Sensitivity and Specificity Spatial Behavior - drug effects Spatial Behavior - physiology Time Factors |
| title | Impaired Recognition Memory in Rats after Damage to the Hippocampus |
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