Neurobeachin: A Protein Kinase A-Anchoring, beige/Chediak-Higashi Protein Homolog Implicated in Neuronal Membrane Traffic

We describe the identification and initial characterization of neurobeachin, a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site (K(d), 10 nm) for the type II regulatory subunit of protein kinase A (PKA RII). Neurobeachin is peripherally associated with pleomorphic tub...

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Veröffentlicht in:	The Journal of neuroscience 2000-12, Vol.20 (23), p.8551-8565
Hauptverfasser:	Wang, Xiaolu, Herberg, Friedrich W, Laue, Michael M, Wullner, Christiane, Hu, Bin, Petrasch-Parwez, Elisabeth, Kilimann, Manfred W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Brefeldin A - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Chediak-Higashi Syndrome - genetics Chickens Cloning, Molecular COP-Coated Vesicles - metabolism COS Cells Cyclic AMP-Dependent Protein Kinase Type II Cyclic AMP-Dependent Protein Kinases - metabolism Cytosol - metabolism Golgi Apparatus - drug effects Golgi Apparatus - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Helminth Proteins - genetics Intracellular Membranes - metabolism Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - drug effects Neurons - metabolism PC12 Cells Protein Structure, Tertiary - genetics Protein Synthesis Inhibitors - pharmacology Protein Transport - drug effects Protein Transport - genetics Proteins - genetics Rats Sequence Homology, Amino Acid
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